A prototype hybrid intraoperative probe for ovarian cancer detection

doi:10.1364/OE.17.007245

A prototype hybrid intraoperative probe for ovarian cancer detection

John Gamelin, Yi Yang, Nrushingh Biswal, Yueli Chen, Shikui Yan, Xiaoguang Zhang, Mozafareddin Karemeddini, Molly Brewer, and Quing Zhu »View Author Affiliations

Optics Express, Vol. 17, Issue 9, pp. 7245-7258 (2009)
http://dx.doi.org/10.1364/OE.17.007245

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Abstract

A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl²⁰⁴/Cs¹³⁷ sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4440) Medical optics and biotechnology : ObGyn
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 22, 2009
Revised Manuscript: April 3, 2009
Manuscript Accepted: April 4, 2009
Published: April 17, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
John Gamelin, Yi Yang, Nrushingh Biswal, Yueli Chen, Shikui Yan, Xiaoguang Zhang, Mozafareddin Karemeddini, Molly Brewer, and Quing Zhu, "A prototype hybrid intraoperative probe for ovarian cancer detection," Opt. Express 17, 7245-7258 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-17-9-7245

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References

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005). [CrossRef] [PubMed]
N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005). [CrossRef] [PubMed]
Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005). [CrossRef]
Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006). [CrossRef]
R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006). [CrossRef] [PubMed]
N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005). [PubMed]
S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007). [CrossRef]
F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994). [CrossRef] [PubMed]
R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002). [CrossRef] [PubMed]
S. A. Gulec, F. Daghighian, and R. Essner, "PET-probe: Evaluation of technical performance and clinical utility of a handheld high-energy gamma probe in oncologic surgery," Ann. Surg. Oncol. (2006). [CrossRef] [PubMed]
E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999). [CrossRef] [PubMed]
M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004). [CrossRef] [PubMed]
R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001). [CrossRef] [PubMed]
M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007). [CrossRef] [PubMed]
R. R. Raylman, "Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In," J. Nucl. Med. 42, 352-360 (2001). [PubMed]
V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008). [CrossRef]
S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005). [CrossRef] [PubMed]
D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005). [CrossRef]
V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005). [CrossRef]
A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003). [CrossRef]
S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999). [CrossRef]
E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006). [CrossRef] [PubMed]
J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999). [PubMed]
H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002). [CrossRef] [PubMed]
M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004). [PubMed]
Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003). [CrossRef] [PubMed]
D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005). [CrossRef] [PubMed]
S. R. Cherry, J. Sorenson, and M. E. Phelps, Physics in Nuclear Medicine, Third Edition, (Saunders, 2003). Saunders.
H. Tan, W. Hennig, Y. Chu, M. Momayezi, and W. Warburton, "Extending the operation of a position-sensitive photomultiplier tube to 1 million counts per second," Nucl. Inst. Meth. Phys. Res. (2007).

Aretz, H. T.
Avril, N.
Barton, J. K.
Bonzom, S.
Boppart, S. A.
Bouma, B. E.
Brands, W. R.
Brewer, M.
Brewer, M. A.
Brezinski, M. E.
Bristow, R. E.
Buck, A.
Burian, M.
Chak, A.
Chang, W.
Charon, Y.
Chauhan, A.
Chen, Y.
Cirocco, M.
Dadparvar, S.
Daghighian, F.
Das, A.
Davis, J. R.
Duval, A. A.
Escano, M. F.
Eshaghian, B.
Essner, R.
Fisher, S. J.
Fishman, E. K.
Flotte, T.
Fong, Y.
Fujii, S.
Fujimoto, J. G.
Gardiner, G.
Ghazarossian, V.
Giuliano, A. E.
Giuntoli, R. L. N.
Gmitro, A. F.
Goodman, A.
Gordon, M. L.
Graeff, H.
Gregory, K.
Haber, G. B.
Halpern, E. F.
Hama, Y.
Hee, M. R.
Hoffman, E. J.
Houser, S. L.
Hoyer, P. B.
Hoying, J. B.
Huang, D.
Humm, J.
Hunt, K.
Isenberg, G.
Iwanczyk, J. S.
Jana, S.
Janecek, M.
Jang, I. K.
Jesser, C. A.
Jungbluth, A.
Kanamori, A.
Kandel, G.
Kang, D. H.
Kanter, E. M.
Kauffman, C. R.
Kirkpatrick, N. D.
Kison, P. V.
Kortan, P.
Kuhn, W.
Kumar, R.
Larson, S. M.
Lederman, R. J.
Lefebvre, F.
Libus, J.
Lin, C. P.
MacDonald, L.
Maeda, H.
Marcon, N. E.
Marion, S. L.
Matsumoto, K.
Mazziotta, J. C.
Meisetschlager, G.
Menard, L.
Minato, K.
Nabel, E. G.
Naehrig, J.
Nahrig, J.
Nakamoto, Y.
Nakamura, M.
Negi, A.
Old, L.
Palfi, S.
Pandit-Taskar, N.
Pannu, H. K.
Patt, B. E.
Phelps, M. E.
Piao, D.
Picchio, M.
Piert, M.
Pinot, L.
Pitre, S.
Pitris, C.
Puliafito, C. A.
Qi, B.
Raylman, R. R.
Rollins, A.
Rowland, D. Y.
Russo, P.
Rutke, S.
Sadeghi, M. M.
Saga, T.
Sakamoto, S.
San, H.
Sassen, S.
Schlendorf, K. H.
Schmalfeldt, B.
Schulick, R. D.
Schuman, J. S.
Schwaiger, M.
Senda, M.
Seya, R.
Shenderov, P.
Shishkov, M.
Siebert, R.
Siegel, S.
Siewert, J. R.
Sinusas, A. J.
Sivak, M. V.
Stein, H. J.
Stevens, S. J.
Stinson, W. G.
Strong, V. E.
Swanson, E. A.
Tang, S. J.
Tarutani, K.
Tearney, G. J.
Tornai, M. P.
Tsugita, R.
Utzinger, U.
Vitkin, I. A.
Wahl, R. L.
Walker, R. M.
Weber, W. A.
Werner, M.
William Strauss, H.
Willis, J. E.
Wilson, B. C.
Wolf, B.
Wong, R. C.
Wong, W. D.
Yabushita, H.
Yamaguchi, Y.
Yamamoto, S.
Yang, V. X.
Zhang, J.
Zhu, Q.
Ziegler, S.

Am. J. Opthalmol.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003). [CrossRef]

Ann. Nucl. Med.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005). [CrossRef] [PubMed]

Br. J. Obs. and Gyn.

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999). [CrossRef]

Cancer J.

R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002). [CrossRef] [PubMed]

Circulation

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002). [CrossRef] [PubMed]

Eur. J. Nucl. Med.

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999). [CrossRef] [PubMed]

Eur. J. Nucl. Med. Mol. Imaging

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007). [CrossRef] [PubMed]

Expert Rev. Anticancer Ther.

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006). [CrossRef] [PubMed]

Gastroint. Endosc.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005). [CrossRef]
V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005). [CrossRef]

Gynecol. Oncol.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005). [CrossRef] [PubMed]

Heart

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999). [PubMed]

IEEE T. Nucl. Sci.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007). [CrossRef]

Intl. J. Clin. Oncol.

Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006). [CrossRef]

Intl. J. Gyn. Cancer

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005). [CrossRef]

J. Biomed. Opt.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006). [CrossRef] [PubMed]
D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005). [CrossRef] [PubMed]

J. Clin. Oncol.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005). [CrossRef] [PubMed]

J. Nucl. Med.

N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005). [PubMed]
R. R. Raylman, "Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In," J. Nucl. Med. 42, 352-360 (2001). [PubMed]

Med. Phys.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994). [CrossRef] [PubMed]

Mol. Imaging Biol.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004). [CrossRef] [PubMed]

Nucl. Med. Commun.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001). [CrossRef] [PubMed]

Opt. Lett.

Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003). [CrossRef] [PubMed]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]

Surg. Endosc.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008). [CrossRef]

Technol. Cancer Res.Treat.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004). [PubMed]

Other

S. R. Cherry, J. Sorenson, and M. E. Phelps, Physics in Nuclear Medicine, Third Edition, (Saunders, 2003). Saunders.
H. Tan, W. Hennig, Y. Chu, M. Momayezi, and W. Warburton, "Extending the operation of a position-sensitive photomultiplier tube to 1 million counts per second," Nucl. Inst. Meth. Phys. Res. (2007).
S. A. Gulec, F. Daghighian, and R. Essner, "PET-probe: Evaluation of technical performance and clinical utility of a handheld high-energy gamma probe in oncologic surgery," Ann. Surg. Oncol. (2006). [CrossRef] [PubMed]

2008, Strong, Surg. Endosc.
2007, Bonzom, IEEE T. Nucl. Sci.
2007, Piert, Eur. J. Nucl. Med. Mol. Imaging
2006, Hama, Intl. J. Clin. Oncol.
2006, Kumar, Expert Rev. Anticancer Ther.
2006, Kanter, J. Biomed. Opt.
2005, Yamamoto, Ann. Nucl. Med.
2005, Piao, J. Biomed. Opt.
2005, Pandit-Taskar, J. Nucl. Med.
2005, Bristow, Gynecol. Oncol.
2005, Avril, J. Clin. Oncol.
2005, Nakamoto, Intl. J. Gyn. Cancer
2005, Isenberg, Gastroint. Endosc.
2005, Yang, Gastroint. Endosc.
2004, Janecek, Mol. Imaging Biol.
2004, Brewer, Technol. Cancer Res.Treat.
2003, Zhu, Opt. Lett.
2003, Kanamori, Am. J. Opthalmol.
2002, Essner, Cancer J.
2002, Yabushita, Circulation
2001, Lederman, Nucl. Med. Commun.
2001, Raylman, J. Nucl. Med.
1999, Boppart, Br. J. Obs. and Gyn.
1999, Hoffman, Eur. J. Nucl. Med.
1999, Fujimoto, Heart
1994, Daghighian, Med. Phys.
1991, Huang, Science

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[1] R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005). [CrossRef] [PubMed]

[2] N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005). [CrossRef] [PubMed]

[3] Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005). [CrossRef]

[4] Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006). [CrossRef]

[5] R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006). [CrossRef] [PubMed]

[6] N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005). [PubMed]

[7] S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007). [CrossRef]

[8] F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994). [CrossRef] [PubMed]

[9] R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002). [CrossRef] [PubMed]

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Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

A prototype hybrid intraoperative probe for ovarian cancer detection