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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

A prototype hybrid intraoperative probe for ovarian cancer detection

John Gamelin, Yi Yang, Nrusingh Biswal, Yueli Chen, Shikui Yan, Xiaoguang Zhang, Mozafareddin Karemeddini, Molly Brewer, and Quing Zhu  »View Author Affiliations

Optics Express, Vol. 17, Issue 9, pp. 7245-7258 (2009)

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A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4440) Medical optics and biotechnology : ObGyn
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 22, 2009
Revised Manuscript: April 3, 2009
Manuscript Accepted: April 4, 2009
Published: April 17, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

John Gamelin, Yi Yang, Nrushingh Biswal, Yueli Chen, Shikui Yan, Xiaoguang Zhang, Mozafareddin Karemeddini, Molly Brewer, and Quing Zhu, "A prototype hybrid intraoperative probe for ovarian cancer detection," Opt. Express 17, 7245-7258 (2009)

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