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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 2 — Jan. 21, 2010

Whispering gallery mode bio-sensor 
for label-free detection of single molecules: thermo-optic vs. reactive mechanism

S. Arnold, S. I. Shopova, and S. Holler  »View Author Affiliations

Optics Express, Vol. 18, Issue 1, pp. 281-287 (2010)

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Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermo-optic mechanism should “greatly enhance” wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (108), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 μm radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed.

© 2009 OSA

OCIS Codes
(040.1880) Detectors : Detection
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3990) Optical devices : Micro-optical devices

ToC Category:

Original Manuscript: November 6, 2009
Revised Manuscript: December 14, 2009
Manuscript Accepted: December 15, 2009
Published: December 23, 2009

Virtual Issues
Vol. 5, Iss. 2 Virtual Journal for Biomedical Optics

S. Arnold, S. I. Shopova, and S. Holler, "Whispering gallery mode bio-sensor 
for label-free detection of single molecules: thermo-optic vs. reactive mechanism," Opt. Express 18, 281-287 (2010)

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