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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo

R. Nika Razansky, Amir Rosenthal, George Mallas, Daniel Razansky, Farouc A. Jaffer, and Vasilis Ntziachristos  »View Author Affiliations


Optics Express, Vol. 18, Issue 11, pp. 11372-11381 (2010)
http://dx.doi.org/10.1364/OE.18.011372


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Abstract

Abstract: Detection of high-risk coronary arterial plaques prior to rupture remains an unmet clinical challenge, in part due to the stringent resolution and sensitivity requirements for in vivo human coronary arterial imaging. To address this need, we have developed a near-infrared (NIR) fluorescence imaging catheter system for intra-vascular molecular imaging of atherosclerosis in coronary artery-sized vessels, capable of resolving two-dimensional fluorescence activity in hollow organs, such as blood vessels. Based on a rotational fiber design, the catheter system illuminates and detects perpendicular to the rotational axis, while an automated pullback mechanism enables visualization along blood vessels with a scan speed of up to 1.5 mm/sec. We demonstrate the previously undocumented capacity to produce intravascular NIR fluorescence images of hollow organs in vivo and showcase the performance metrics of the system developed using blood vessel mimicking phantoms. This imaging approach is geared toward in vivo molecular imaging of atherosclerotic biomarkers and is engineered to allow seamless integration into the cardiac catheterization laboratory.

© 2010 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.2350) Imaging systems : Fiber optics imaging
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 26, 2010
Revised Manuscript: March 27, 2010
Manuscript Accepted: March 28, 2010
Published: May 14, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
R. Nika Razansky, Amir Rosenthal, George Mallas, Daniel Razansky, Farouc A. Jaffer, and Vasilis Ntziachristos, "Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo," Opt. Express 18, 11372-11381 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-11-11372


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