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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Fourier domain pump-probe optical coherence tomography imaging of Melanin

Desmond Jacob, Ryan L. Shelton, and Brian E. Applegate  »View Author Affiliations


Optics Express, Vol. 18, Issue 12, pp. 12399-12410 (2010)
http://dx.doi.org/10.1364/OE.18.012399


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Abstract

We report the development of a two-color Fourier domain Pump-Probe Optical Coherence Tomography (PPOCT) system. Tissue phantom experiments to characterize the system performance demonstrated imaging depths in excess of 725 μm, nearly comparable to the base Optical Coherence Tomography system. PPOCT A-line rates were also demonstrated in excess of 1 kHz. The physical origin of the PPOCT signal was investigated with a series of experiments which revealed that the signal is a mixture of short and long lifetime component signals. The short lifetime component was attributed to transient absorption while the long lifetime component may be due to a mixture of transient absorption and thermal effects. Ex vivo images of porcine iris demonstrated the potential for imaging melanin in the eye, where cancer of the melanocytes is the most common form of eye cancer in adults.

© 2010 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4180) Nonlinear optics : Multiphoton processes

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 8, 2010
Revised Manuscript: May 11, 2010
Manuscript Accepted: May 14, 2010
Published: May 26, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Desmond Jacob, Ryan L. Shelton, and Brian E. Applegate, "Fourier domain pump-probe optical coherence tomography imaging of Melanin," Opt. Express 18, 12399-12410 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-12-12399


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