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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Dynamic spectral-domain optical coherence elastography for tissue characterization

Xing Liang, Steven G. Adie, Renu John, and Stephen A. Boppart  »View Author Affiliations


Optics Express, Vol. 18, Issue 13, pp. 14183-14190 (2010)
http://dx.doi.org/10.1364/OE.18.014183


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Abstract

A dynamic spectral-domain optical coherence elastography (OCE) imaging technique is reported. In this technique, audio-frequency compressive vibrations are generated by a piezoelectric stack as external excitation, and strain rates in the sample are calculated and mapped quantitatively using phase-sensitive spectral-domain optical coherence tomography. At different driving frequencies, this technique provides contrast between sample regions with different mechanical properties, and thus is used to mechanically characterize tissue. We present images of a three-layer silicone tissue phantom and rat tumor tissue ex vivo, based on quantitative strain rate. Both acquisition speed and processing speed are improved dramatically compared with previous OCE imaging techniques. With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications.

© 2010 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 7, 2010
Revised Manuscript: June 8, 2010
Manuscript Accepted: June 14, 2010
Published: June 16, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Xing Liang, Steven G. Adie, Renu John, and Stephen A. Boppart, "Dynamic spectral-domain optical coherence elastography for tissue characterization," Opt. Express 18, 14183-14190 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-13-14183


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