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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

A resource for the assessment of lung nodule size estimation methods: database of thoracic CT scans of an anthropomorphic phantom

Marios A. Gavrielides, Lisa M. Kinnard, Kyle J. Myers, Jennifer Peregoy, William F. Pritchard, Rongping Zeng, Juan Esparza, John Karanian, and Nicholas Petrick  »View Author Affiliations


Optics Express, Vol. 18, Issue 14, pp. 15244-15255 (2010)
http://dx.doi.org/10.1364/OE.18.015244


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Abstract

A number of interrelated factors can affect the precision and accuracy of lung nodule size estimation. To quantify the effect of these factors, we have been conducting phantom CT studies using an anthropomorphic thoracic phantom containing a vasculature insert to which synthetic nodules were inserted or attached. Ten repeat scans were acquired on different multi-detector scanners, using several sets of acquisition and reconstruction protocols and various nodule characteristics (size, shape, density, location). This study design enables both bias and variance analysis for the nodule size estimation task. The resulting database is in the process of becoming publicly available as a resource to facilitate the assessment of lung nodule size estimation methodologies and to enable comparisons between different methods regarding measurement error. This resource complements public databases of clinical data and will contribute towards the development of procedures that will maximize the utility of CT imaging for lung cancer screening and tumor therapy evaluation.

© 2010 OSA

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(110.7440) Imaging systems : X-ray imaging
(110.1758) Imaging systems : Computational imaging
(110.6955) Imaging systems : Tomographic imaging

History
Original Manuscript: November 18, 2009
Revised Manuscript: June 10, 2010
Manuscript Accepted: June 11, 2010
Published: July 2, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics
Imaging in Diagnosis and Treatment of Lung Cancer (2010) Optics Express

Citation
Marios A. Gavrielides, Lisa M. Kinnard, Kyle J. Myers, Jennifer Peregoy, William F. Pritchard, Rongping Zeng, Juan Esparza, John Karanian, and Nicholas Petrick, "A resource for the assessment of lung nodule size estimation methods: database of thoracic CT scans of an anthropomorphic phantom," Opt. Express 18, 15244-15255 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-14-15244


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