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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 12 — Sep. 30, 2010

X-ray phase contrast microscopy at 300 nm resolution with laboratory sources

Daniele Pelliccia, Andrea Sorrentino, Inna Bukreeva, Alessia Cedola, Fernando Scarinci, Mihaela Ilie, Anna Maria Gerardino, Michela Fratini, and Stefano Lagomarsino  »View Author Affiliations


Optics Express, Vol. 18, Issue 15, pp. 15998-16004 (2010)
http://dx.doi.org/10.1364/OE.18.015998


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Abstract

We report the performance of an X-ray phase contrast microscope for laboratory sources with 300 nm spatial resolution. The microscope is based on a commercial X-ray microfocus source equipped with a planar X-ray waveguide able to produce a sub-micrometer x-ray beam in one dimension. Phase contrast images of representative samples are reported. The achieved contrast and resolution is discussed for different configurations. The proposed approach could represent a simple, inexpensive, solution for sub-micrometer resolution imaging with small laboratory setups.

© 2010 OSA

OCIS Codes
(340.0340) X-ray optics : X-ray optics
(340.7440) X-ray optics : X-ray imaging
(340.7460) X-ray optics : X-ray microscopy

ToC Category:
X-ray Optics

History
Original Manuscript: March 15, 2010
Revised Manuscript: April 19, 2010
Manuscript Accepted: May 9, 2010
Published: July 14, 2010

Virtual Issues
Vol. 5, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Daniele Pelliccia, Andrea Sorrentino, Inna Bukreeva, Alessia Cedola, Fernando Scarinci, Mihaela Ilie, Anna Maria Gerardino, Michela Fratini, and Stefano Lagomarsino, "X-ray phase contrast microscopy at 300 nm resolution with laboratory sources," Opt. Express 18, 15998-16004 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-15-15998


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References

  1. U. Bonse and M. Hart, “An x-ray interferometer,” Appl. Phys. Lett. 6(8), 155–156 (1965). [CrossRef]
  2. A. Momose, “Phase-contrast X-ray imaging based on interferometry,” J. Synchrotron Radiat. 9(3), 136–142 (2002). [CrossRef] [PubMed]
  3. C. David, B. Nöhammer, H. H. Solak, and E. Ziegler, “Differential x-ray phase contrast imaging using a shearing interferometer,” Appl. Phys. Lett. 81(17), 3287–3289 (2002). [CrossRef]
  4. D. Chapman, W. Thomlinson, R. E. Johnston, D. Washburn, E. Pisano, N. Gmür, Z. Zhong, R. Menk, F. Arfelli, and D. Sayers, “Diffraction enhanced x-ray imaging,” Phys. Med. Biol. 42(11), 2015–2025 (1997). [CrossRef] [PubMed]
  5. P. Cloetens, R. Barrett, J. Baruchel, J.-P. Guigay, and M. Schlenker, “Phase objects in synchrotron radiation hard x-ray imaging,” J. Phys. D Appl. Phys. 29(1), 133–146 (1996). [CrossRef]
  6. K. A. Nugent, T. E. Gureyev, D. J. Cookson, D. Paganin, and Z. Barnea, “Quantitative phase imaging using hard x-rays,” Phys. Rev. Lett. 77(14), 2961–2964 (1996). [CrossRef] [PubMed]
  7. A. Pogany, D. Gao, and S. W. Wilkins, “Contrast and resolution in imaging with a microfocus x-ray source,” Rev. Sci. Instrum. 68(7), 2774–2782 (1997). [CrossRef]
  8. S. V. Gasilov, A. Ya. Faenov, T. A. Pikuz, Y. Fukuda, M. Kando, T. Kawachi, I. Yu. Skobelev, H. Daido, Y. Kato, and S. V. Bulanov, “Wide-field-of-view phase-contrast imaging of nanostructures with a comparatively large polychromatic soft x-ray plasma source,” Opt. Lett. 34(21), 3268–3270 (2009). [CrossRef] [PubMed]
  9. S. Almaviva, F. Bonfigli, I. Franzini, A. Lai, R. M. Montereali, D. Pelliccia, A. Cedola, and S. Lagomarsino, “Hard x-ray contact microscopy with 250 nm spatial resolution using a LiF film detector and a tabletop microsource,” Appl. Phys. Lett. 89(5), 054102 (2006). [CrossRef]
  10. R. Toth, J. C. Kieffer, S. Fourmaux, T. Ozaki, and A. Krol, “In-line phase-contrast imaging with a laser-based hard x-ray source,” Rev. Sci. Instrum. 76(8), 083701 (2005). [CrossRef]
  11. S. C. Mayo, P. R. Miller, S. W. Wilkins, T. J. Davis, D. Gao, T. E. Gureyev, D. Paganin, D. J. Parry, A. Pogany, and A. W. Stevenson, “Quantitative X-ray projection microscopy: phase-contrast and multi-spectral imaging,” J. Microsc. 207(2), 79–96 (2002). [CrossRef] [PubMed]
  12. S. C. Mayo, T. J. Davis, T. E. Gureyev, P. R. Miller, D. Paganin, A. Pogany, A. W. Stevenson, and S. W. Wilkins, “X-ray phase-contrast microscopy and microtomography,” Opt. Express 11(19), 2289–2302 (2003). [CrossRef] [PubMed]
  13. S. Lagomarsino, W. Jark, S. Di Fonzo, A. Cedola, B. Mueller, P. Engstrom, and C. Riekel, “Sub-micro-meter X-ray beam production by a thin film wave-guide,” J. Appl. Phys. 79(8), 4471–4473 (1996). [CrossRef]
  14. W. Jark, S. Di Fonzo, S. Lagomarsino, A. Cedola, E. di Fabrizio, A. Bram, and C. Riekel, “Properties of a submicrometer x-ray beam at the exit of a waveguide,” J. Appl. Phys. 80(9), 4831–4836 (1996). [CrossRef]
  15. D. Pelliccia, I. Bukreeva, M. Ilie, W. Jark, A. Cedola, F. Scarinci, and S. Lagomarsino, “Computer simulations and experimental results on air-gap X-ray waveguides,” Spectrochim. Acta, B At. Spectrosc. 62(6-7), 615–621 (2007). [CrossRef]
  16. L. De Caro, C. Giannini, S. Di Fonzo, W. Jark, A. Cedola, and S. Lagomarsino, “Spatial coherence of x-ray planar waveguide exiting radiation,” Opt. Commun. 217(1-6), 31–45 (2003). [CrossRef]
  17. L. De Caro, A. Cedola, C. Giannini, I. Bukreeva, and S. Lagomarsino, “In-line phase-contrast imaging for strong absorbing objects,” Phys. Med. Biol. 53(22), 6619–6637 (2008). [CrossRef] [PubMed]
  18. I. Bukreeva, D. Pelliccia, A. Cedola, F. Scarinci, M. Ilie, C. Giannini, L. De Caro, and S. Lagomarsino, “Analysis of tapered front-coupling X-ray waveguides,” J. Synchrotron Radiat. 17(1), 61–68 (2010). [CrossRef]
  19. M. Born, and E. Wolf, Principles of Optics (Pergamon Press, Oxford, 1986).
  20. S. Di Fonzo, W. Jark, S. Lagomarsino, C. Giannini, L. De Caro, A. Cedola, and M. Müller, “Non-destructive determination of local strain with 100-nanometre spatial resolution,” Nature 403(6770), 638–640 (2000). [CrossRef] [PubMed]
  21. L. De Caro, C. Giannini, D. Pelliccia, C. Mocuta, T. H. Metzger, A. Guagliardi, A. Cedola, I. Burkeeva, and S. Lagomarsino, “In-line holography and coherent diffractive imaging with x-ray waveguides,” Phys. Rev. B 77(8), 081408 (2008). [CrossRef]
  22. F. Pfeiffer, C. David, M. Burghammer, C. Riekel, and T. Salditt, “Two-dimensional x-ray waveguides and point sources,” Science 297(5579), 230–234 (2002). [CrossRef] [PubMed]

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