Optics InfoBase > Virtual Journal for Biomedical Optics > Volume 5 > Issue 12 > Page 16217
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High index contrast polymer waveguide platform for integrated biophotonicsJennifer Halldorsson, Nina B. Arnfinnsdottir, Asta B. Jonsdottir, Björn Agnarsson, and Kristjan Leosson »View Author Affiliations
Jennifer Halldorsson,1
Nina B. Arnfinnsdottir,1
Asta B. Jonsdottir,2,3
Björn Agnarsson,1
and Kristjan Leosson1,*
1Department of Physics, Science Institute, University of Iceland, Dunhagi 3,IS-107 Reykjavik, Iceland 2Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland 3Currently with the Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchinson/MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK *Corresponding author: kleos@hi.is |
Optics Express, Vol. 18, Issue 15, pp. 16217-16226 (2010)
http://dx.doi.org/10.1364/OE.18.016217
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Abstract
We present detailed characterization of a unique high-index-contrast integrated optical polymer waveguide platform where the index of the cladding material is closely matched to that of water. Single-mode waveguides designed to operate across a large part of the visible spectrum have been fabricated and waveguide properties, including mode size, bend loss and evanescent coupling have been modeled using effective-index approximation, finite-element and finite-difference time domain methods. Integrated components such as directional couplers for wavelength splitting and ring resonators for refractive-index or temperature sensing have been modeled, fabricated and characterized. The waveguide platform described here is applicable to a wide range of biophotonic applications relying on evanescent-wave sensing or excitation, offering a high level of integration and functionality. The technology is biocompatible and suitable for wafer-level mass production.
© 2010 OSA
OCIS Codes
(130.0130) Integrated optics : Integrated optics
(180.2520) Microscopy : Fluorescence microscopy
(230.7390) Optical devices : Waveguides, planar
(250.5460) Optoelectronics : Polymer waveguides
(280.1415) Remote sensing and sensors : Biological sensing and sensors
ToC Category:
Integrated Optics
History
Original Manuscript: May 20, 2010
Revised Manuscript: July 1, 2010
Manuscript Accepted: July 3, 2010
Published: July 16, 2010
Virtual Issues
Vol. 5, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Jennifer Halldorsson, Nina B. Arnfinnsdottir, Asta B. Jonsdottir, Björn Agnarsson, and Kristjan Leosson, "High index contrast polymer waveguide platform for integrated biophotonics," Opt. Express 18, 16217-16226 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-15-16217
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References
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- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
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- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
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- S. I. Shopova, H. Zhou, X. Fan, and P. Zhang, “Optofluidic ring resonator based dye laser,” Appl. Phys. Lett. 90(22), 221101 (2007). [CrossRef]
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007). [CrossRef] [PubMed]
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- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15(6), 998–1005 (1997). [CrossRef]
- C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12(1), 134–142 (2006). [CrossRef]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- J. C. Galas, J. Torres, M. Belotti, Q. Kou, and Y. Chen, “Microfluidic tunable dye laser with integrated mixer and ring resonator,” Appl. Phys. Lett. 86(26), 264101 (2005). [CrossRef]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- B. Agnarsson, J. Halldorsson, N. Arnfinnsdottir, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Fabrication of planar polymer waveguides for evanescent-wave sensing in aqueous environments,” Microelectron. Eng. 87(1), 56–61 (2010). [CrossRef]
- B. Agnarsson, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Evanescent-wave fluorescence microscopy using symmetric planar waveguides,” Opt. Express 17(7), 5075–5082 (2009). [CrossRef] [PubMed]
- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
- C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12(1), 134–142 (2006). [CrossRef]
- L. J. Guo, “Recent progress in nanoimprint technology and its applications,” J. Phys. D 37(11), R123–R141 (2004). [CrossRef]
- B. Agnarsson, J. Halldorsson, N. Arnfinnsdottir, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Fabrication of planar polymer waveguides for evanescent-wave sensing in aqueous environments,” Microelectron. Eng. 87(1), 56–61 (2010). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15(6), 998–1005 (1997). [CrossRef]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- C. W. Tsao, L. Hromada, J. Liu, P. Kumar, and D. L. DeVoe, “Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment,” Lab Chip 7(4), 499–505 (2007). [CrossRef] [PubMed]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- B. Agnarsson, J. Halldorsson, N. Arnfinnsdottir, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Fabrication of planar polymer waveguides for evanescent-wave sensing in aqueous environments,” Microelectron. Eng. 87(1), 56–61 (2010). [CrossRef]
- B. Agnarsson, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Evanescent-wave fluorescence microscopy using symmetric planar waveguides,” Opt. Express 17(7), 5075–5082 (2009). [CrossRef] [PubMed]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- H. Ma, A. K. Y. Jen, and L. R. Dalton, “Polymer-Based Optical Waveguides: Materials, Processing, and Devices,” Adv. Mater. 14(19), 1339–1365 (2002). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- C. J. Kaalund, “Critically coupled ring resonators for add-drop filtering,” Opt. Commun. 237(4-6), 357–362 (2004). [CrossRef]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
- J. C. Galas, J. Torres, M. Belotti, Q. Kou, and Y. Chen, “Microfluidic tunable dye laser with integrated mixer and ring resonator,” Appl. Phys. Lett. 86(26), 264101 (2005). [CrossRef]
- S. Y. Chou, P. R. Krauss, and P. J. Renstrom, “Nanoimprint lithography,” J. Vac. Sci. Technol. B 14(6), 4129–4133 (1996). [CrossRef]
- C. W. Tsao, L. Hromada, J. Liu, P. Kumar, and D. L. DeVoe, “Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment,” Lab Chip 7(4), 499–505 (2007). [CrossRef] [PubMed]
- B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15(6), 998–1005 (1997). [CrossRef]
- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14(8), 907–912 (2003). [CrossRef]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- B. Agnarsson, J. Halldorsson, N. Arnfinnsdottir, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Fabrication of planar polymer waveguides for evanescent-wave sensing in aqueous environments,” Microelectron. Eng. 87(1), 56–61 (2010). [CrossRef]
- B. Agnarsson, S. Ingthorsson, T. Gudjonsson, and K. Leosson, “Evanescent-wave fluorescence microscopy using symmetric planar waveguides,” Opt. Express 17(7), 5075–5082 (2009). [CrossRef] [PubMed]
- A. Leung, P. M. Shankar, and R. Mutharasan, “A review of fiber-optic biosensors,” Sens. Actuators B Chem. 125(2), 688–703 (2007). [CrossRef]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15(6), 998–1005 (1997). [CrossRef]
- B. Liu, A. Shakouri, and J. E. Bowers, “Wide tunable double ring resonator coupled lasers,” IEEE Photon. Technol. Lett. 14(5), 600–602 (2002). [CrossRef]
- C. W. Tsao, L. Hromada, J. Liu, P. Kumar, and D. L. DeVoe, “Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment,” Lab Chip 7(4), 499–505 (2007). [CrossRef] [PubMed]
- F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14(8), 907–912 (2003). [CrossRef]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007). [CrossRef] [PubMed]
- H. Ma, A. K. Y. Jen, and L. R. Dalton, “Polymer-Based Optical Waveguides: Materials, Processing, and Devices,” Adv. Mater. 14(19), 1339–1365 (2002). [CrossRef]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- E. A. J. Marcatili, “Dielectric rectangular waveguide and directional coupler for integrated optics,” Bell Syst. Tech. J. 48, 2071–2102 (1969).
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14(8), 907–912 (2003). [CrossRef]
- A. Leung, P. M. Shankar, and R. Mutharasan, “A review of fiber-optic biosensors,” Sens. Actuators B Chem. 125(2), 688–703 (2007). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007). [CrossRef] [PubMed]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14(8), 907–912 (2003). [CrossRef]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- S. Y. Chou, P. R. Krauss, and P. J. Renstrom, “Nanoimprint lithography,” J. Vac. Sci. Technol. B 14(6), 4129–4133 (1996). [CrossRef]
- J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef] [PubMed]
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
- F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14(8), 907–912 (2003). [CrossRef]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- B. Liu, A. Shakouri, and J. E. Bowers, “Wide tunable double ring resonator coupled lasers,” IEEE Photon. Technol. Lett. 14(5), 600–602 (2002). [CrossRef]
- A. Leung, P. M. Shankar, and R. Mutharasan, “A review of fiber-optic biosensors,” Sens. Actuators B Chem. 125(2), 688–703 (2007). [CrossRef]
- S. I. Shopova, H. Zhou, X. Fan, and P. Zhang, “Optofluidic ring resonator based dye laser,” Appl. Phys. Lett. 90(22), 221101 (2007). [CrossRef]
- J. C. Galas, J. Torres, M. Belotti, Q. Kou, and Y. Chen, “Microfluidic tunable dye laser with integrated mixer and ring resonator,” Appl. Phys. Lett. 86(26), 264101 (2005). [CrossRef]
- C. W. Tsao, L. Hromada, J. Liu, P. Kumar, and D. L. DeVoe, “Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment,” Lab Chip 7(4), 499–505 (2007). [CrossRef] [PubMed]
- G. Pandraud, T. M. Koster, C. Gui, M. Dijkstra, A. Van Den Berg, and P. V. Lambeck, “Evanescent wave sensing: New features for detection in small volumes,” Sens. Actuators A Phys. 85(1-3), 158–162 (2000). [CrossRef]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Martinez-Vazquez, R. Osellame, G. Cerullo, R. Ramponi, R. van Weeghel, G. A. J. Besselink, and H. H. van den Vlekkert, “Fluorescence monitoring of microchip capillary electrophoresis separation with monolithically integrated waveguides,” Opt. Lett. 33(21), 2503–2505 (2008). [CrossRef] [PubMed]
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
- J. J. Shah, J. Geist, L. E. Locascio, M. Gaitan, M. V. Rao, and W. N. Vreeland, “Surface modification of poly(methyl methacrylate) for improved adsorption of wall coating polymers for microchip electrophoresis,” Electrophoresis 27(19), 3788–3796 (2006). [CrossRef] [PubMed]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
- J. K. Poon, L. Zhu, G. A. DeRose, and A. Yariv, “Transmission and group delay of microring coupled-resonator optical waveguides,” Opt. Lett. 31(4), 456–458 (2006). [CrossRef] [PubMed]
- J. K. S. Poon, L. Zhu, G. A. DeRose, and A. Yariv, “Polymer microring coupled-resonator optical waveguides,” J. Lightwave Technol. 24(4), 1843–1849 (2006). [CrossRef]
- A. Yariv, “Critical coupling and its control in optical waveguide-ring resonator systems,” IEEE Photon. Technol. Lett. 14(4), 483–485 (2002). [CrossRef]
- A. Yariv, “Universal relations for coupling of optical power between microresonators and dielectric waveguides,” Electron. Lett. 36(4), 321–322 (2000). [CrossRef]
- A. Yariv, “Coupled-mode theory for guided-wave optics,” IEEE J. Quantum Electron. 9(9), 919–933 (1973). [CrossRef]
- S. I. Shopova, H. Zhou, X. Fan, and P. Zhang, “Optofluidic ring resonator based dye laser,” Appl. Phys. Lett. 90(22), 221101 (2007). [CrossRef]
- S. I. Shopova, H. Zhou, X. Fan, and P. Zhang, “Optofluidic ring resonator based dye laser,” Appl. Phys. Lett. 90(22), 221101 (2007). [CrossRef]
- J. K. S. Poon, L. Zhu, G. A. DeRose, and A. Yariv, “Polymer microring coupled-resonator optical waveguides,” J. Lightwave Technol. 24(4), 1843–1849 (2006). [CrossRef]
- J. K. Poon, L. Zhu, G. A. DeRose, and A. Yariv, “Transmission and group delay of microring coupled-resonator optical waveguides,” Opt. Lett. 31(4), 456–458 (2006). [CrossRef] [PubMed]
Adv. Mater.
- H. Ma, A. K. Y. Jen, and L. R. Dalton, “Polymer-Based Optical Waveguides: Materials, Processing, and Devices,” Adv. Mater. 14(19), 1339–1365 (2002). [CrossRef]
Appl. Phys. Lett.
- J. C. Galas, J. Torres, M. Belotti, Q. Kou, and Y. Chen, “Microfluidic tunable dye laser with integrated mixer and ring resonator,” Appl. Phys. Lett. 86(26), 264101 (2005). [CrossRef]
- S. I. Shopova, H. Zhou, X. Fan, and P. Zhang, “Optofluidic ring resonator based dye laser,” Appl. Phys. Lett. 90(22), 221101 (2007). [CrossRef]
Appl. Surf. Sci.
- C. Vieu, F. Carcenac, A. Pépin, Y. Chen, M. Mejias, A. Lebib, L. Manin-Ferlazzo, L. Couraud, and H. Launois, “Electron beam lithography: Resolution limits and applications,” Appl. Surf. Sci. 164(1-4), 111–117 (2000). [CrossRef]
Bell Syst. Tech. J.
- E. A. J. Marcatili, “Dielectric rectangular waveguide and directional coupler for integrated optics,” Bell Syst. Tech. J. 48, 2071–2102 (1969).
Biosens. Bioelectron.
- A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, “A universal biosensing platform based on optical micro-ring resonators,” Biosens. Bioelectron. 23(7), 939–944 (2008). [CrossRef]
Electron. Lett.
- A. Yariv, “Universal relations for coupling of optical power between microresonators and dielectric waveguides,” Electron. Lett. 36(4), 321–322 (2000). [CrossRef]
Electrophoresis
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IEEE J. Quantum Electron.
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IEEE J. Sel. Top. Quantum Electron.
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IEEE Photon. Technol. Lett.
- A. Yariv, “Critical coupling and its control in optical waveguide-ring resonator systems,” IEEE Photon. Technol. Lett. 14(4), 483–485 (2002). [CrossRef]
- B. Liu, A. Shakouri, and J. E. Bowers, “Wide tunable double ring resonator coupled lasers,” IEEE Photon. Technol. Lett. 14(5), 600–602 (2002). [CrossRef]
J. Lightwave Technol.
- B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15(6), 998–1005 (1997). [CrossRef]
- J. K. S. Poon, L. Zhu, G. A. DeRose, and A. Yariv, “Polymer microring coupled-resonator optical waveguides,” J. Lightwave Technol. 24(4), 1843–1849 (2006). [CrossRef]
J. Phys. D
- L. J. Guo, “Recent progress in nanoimprint technology and its applications,” J. Phys. D 37(11), R123–R141 (2004). [CrossRef]
J. Vac. Sci. Technol. B
- S. Y. Chou, P. R. Krauss, and P. J. Renstrom, “Nanoimprint lithography,” J. Vac. Sci. Technol. B 14(6), 4129–4133 (1996). [CrossRef]
Lab Chip
- A. Piruska, I. Nikcevic, S. H. Lee, C. Ahn, W. R. Heineman, P. A. Limbach, and C. J. Seliskar, “The autofluorescence of plastic materials and chips measured under laser irradiation,” Lab Chip 5(12), 1348–1354 (2005). [CrossRef] [PubMed]
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