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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 5, Iss. 14 — Nov. 16, 2010

Label-free optical biosensing using a horizontal air-slot SiNx microdisk resonator

Shinyoung Lee, Seok Chan Eom, Jee Soo Chang, Chul Huh, Gun Yong Sung, and Jung H. Shin  »View Author Affiliations


Optics Express, Vol. 18, Issue 20, pp. 20638-20644 (2010)
http://dx.doi.org/10.1364/OE.18.020638


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Abstract

We demonstrate label-free optical biosensing using a horizontal air-slotted silicon-rich silicon nitride (SiNx) microdisk resonator. Due to the strong confinement of light in the air-slot, a large resonance shift of 6.2 nm is observed upon reaction of the biotin-functionalized disk with a streptavidin solution with concentration of 2.5 μg/ml. Assuming a linear relationship between resonance shift and streptavidin concentration, we estimate the sensitivity to be 2.5 ± 0.2 nm/(μg/ml). Comparing this value with surface sensitivity of 5.7 nm/nm calculated using FDTD simulations, a detection limit of 30 ± 2 ng/ml, is extrapolated.

© 2010 OSA

OCIS Codes
(230.5750) Optical devices : Resonators
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: August 3, 2010
Revised Manuscript: September 7, 2010
Manuscript Accepted: September 7, 2010
Published: September 14, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Citation
Shinyoung Lee, Seok Chan Eom, Jee Soo Chang, Chul Huh, Gun Yong Sung, and Jung H. Shin, "Label-free optical biosensing using a horizontal air-slot SiNx microdisk resonator," Opt. Express 18, 20638-20644 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-20-20638


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