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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Photothermal nanoblade for patterned cell membrane cutting

Ting-Hsiang Wu, Tara Teslaa, Michael A. Teitell, and Pei-Yu Chiou  »View Author Affiliations

Optics Express, Vol. 18, Issue 22, pp. 23153-23160 (2010)

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We report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy and convert it into a highly localized and specifically shaped explosive vapor bubble. Rapid bubble expansion and collapse punctures a lightly-contacting cell membrane via high-speed fluidic flows and induced transient shear stress. The membrane cutting pattern is controlled by the metallic nanostructure configuration, laser pulse polarization, and energy. Highly controllable, sub-micron sized circular hole pairs to half moon-like, or cat-door shaped, membrane cuts were realized in glutaraldehyde treated HeLa cells.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(350.5340) Other areas of optics : Photothermal effects
(140.3538) Lasers and laser optics : Lasers, pulsed

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 3, 2010
Revised Manuscript: September 20, 2010
Manuscript Accepted: September 21, 2010
Published: October 19, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Ting-Hsiang Wu, Tara Teslaa, Michael A. Teitell, and Pei-Yu Chiou, "Photothermal nanoblade for 
patterned cell membrane cutting," Opt. Express 18, 23153-23160 (2010)

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