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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 5 — Mar. 17, 2010

Use of a multi-spectral camera in the characterization of skin wounds

Ali Basiri, Marjan Nabili, Scott Mathews, Alex Libin, Suzanne Groah, Herke J. Noordmans, and Jessica C. Ramella-Roman  »View Author Affiliations


Optics Express, Vol. 18, Issue 4, pp. 3244-3257 (2010)
http://dx.doi.org/10.1364/OE.18.003244


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Abstract

Skin breakdown is a prevalent and costly medical condition worldwide, with the etiologic and healing processes being complex and multifactorial. Quantitative assessment of wound healing is challenging due to the subjective measurement of wound size and related characteristics. We propose that in vivo spectral reflectance measurements can serve as valuable clinical monitoring tool/device in the study of wound healing. We have designed a multi spectral camera able to acquire 18 wavelength sensitive images in a single snapshot. A lenslets array in front of a digital camera is combined with narrowband filters (bandwidth 10 nm) ranging from 460 to 886nm. Images taken with the spectroscopic camera are composed of 18 identical sub-images, each carrying different spectral information, that can be used in the assessment of skin chromophores. A clinical trial based on a repeated measures design was conducted at the National Rehabilitation Hospital on 15 individuals to assess whether Poly Carboxy Methyl Glucose Sulfate (PCMGS, CACIPLIQ20), a bio-engineered component of the extracellular matrix of the skin, is effective at promoting healing of a variety of wounds. Multi spectral images collected at different wavelengths combined with optical skin models were used to quantify skin oxygen saturation and its relation to the traditional measures of wound healing.

© 2010 OSA

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 29, 2009
Revised Manuscript: January 13, 2010
Manuscript Accepted: January 14, 2010
Published: February 1, 2010

Virtual Issues
Vol. 5, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Ali Basiri, Marjan Nabili, Scott Mathews, Alex Libin, Suzanne Groah, Herke J. Noordmans, and Jessica C. Ramella-Roman, "Use of a multi-spectral camera in the characterization of skin wounds," Opt. Express 18, 3244-3257 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-4-3244


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References

  1. A. Vogel, V. V. Chernomordik, J. D. Riley, M. Hassan, F. Amyot, B. Dasgeb, S. G. Demos, R. Pursley, R. F. Little, R. Yarchoan, Y. Tao, and A. H. Gandjbakhche, “Using noninvasive multispectral imaging to quantitatively assess tissue vasculature,” J. Biomed. Opt. 12, 051604.1–12 (2004).
  2. G. N. Stamatas, M. Southall, and N. Kollias, “In vivo monitoring of cutaneous edema using spectral imaging in the visible and near infrared,” The society for investigative dermatology 126(8), 1753–1760 (2006). [CrossRef]
  3. H. J. Noordmans, R. De Roode, M. Staring, and R. Verdaasdonk, “Registration and analysis of in-vivo multi-spectral images for correction of motion and comparison in time,” Proc. SPIE, 7. 608106.1-.9 (2006).
  4. R. De Roode, H. J. Noordmans, R. Verdaasdonk, and V. Sigurdsson, “MULTISPECTRAL DETECTORS: Multispectral system evaluates treatments in dermatology,” Laser Focus World. 42 (Apr 2006) www.laserfocusworld.com .
  5. T. Binzoni, A. Vogel, A. H. Gandjbakhche, and R. Marchesini, “Detection limits of multi-spectral optical imaging under the skin surface,” Phys. Med. Biol. 53(3), 617–636 (2008). [CrossRef] [PubMed]
  6. I. V. Meglinski and S. J. Matcher, “Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions,” Physiol. Meas. 23(4), 741–753 (2002). [CrossRef] [PubMed]
  7. I. V. Meglinski and S. J. Matcher, “Computer simulation of the sin reflectance spectra,” Comput. Methods Programs Biomed. 70(2), 44–50 (2003). [CrossRef]
  8. J. Ramella-Roman and S. Mathews, “Spectroscopic Measurement of Oxygen Saturation in the Retina,” IEEE J. Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007). [CrossRef]
  9. S. A. Mathews, “Design and fabrication of a low-cost, multispectral imaging system,” Appl. Opt. 47(28), F71–F76 (2008). [CrossRef] [PubMed]
  10. J. Ramella - Roman, S. Mathews, H. Kandiamalla, A. Nabili, D. Duncan, S. A. D'Anna, S. M. Shah, and Q. D. Nguyen, “Measurement of oxygen saturation in the retina with a spectroscopic sesitive multi aperture camera,” Opt. Express 16(9), 6170–6182 (2008) (i). [CrossRef] [PubMed]
  11. T. Moffitt, Y. Chen, and S.A. Prahl. “Preparation and characterization of polyurethane optical phantoms,” J. Biomed. Opt. 11 041103.1–10 (2006).
  12. L. H. Wang, S. L. Jacques, and L. Q. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995). [CrossRef] [PubMed]
  13. G. N. Stamatas and N. Kollias, “In vivo documentation of cutaneous inflammation using spectral imaging,” J. Biomed. Opt. 12(5), 051603 (2007). [CrossRef] [PubMed]
  14. S. Iyad, Saidi, 1992 Transcutaneous optical measurement of hyperbilirubinemia in neonates. Ph.D. dissertation, Rice University, Houston, TX, USA.
  15. S. Takatani and M. D. Graham, “Theoretical analysis of diffuse reflectance from a two-layer tissue model,” IEEE Trans. Biomed. Eng. BME-26(12), 656–664 (1979). [CrossRef]
  16. Center for Wound Healing,and Hyperbaric Medicine, “Smoking and woundhealing,” Wound Healing Center., Trinitas Hospital. (2001). http://www.woundhealingcenter.org/SmokingandWound Healing.pdf .C. Ueno, T. Hunt, H. Hopf, “Using Physiology to improve surgical wound outcomes,” Plast. Reconstr. Surg. 117, 59S–71S (2006)
  17. Some portions of this paper have appeared in M. Nabili, J. C. Ramella-Roman, Assessment of skin wound healing with a multi-aperture camera, Photonics in Dermatology and Plastic Surgery, Proceedings of SPIE Vol. 7161A, 2009.

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