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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 7 — Apr. 26, 2010

A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients

Anthony Kim, Mathieu Roy, Farhan Dadani, and Brian C. Wilson  »View Author Affiliations


Optics Express, Vol. 18, Issue 6, pp. 5580-5594 (2010)
http://dx.doi.org/10.1364/OE.18.005580


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Abstract

Measurement of tissue optical absorption and (transport) reduced scattering coefficients (μa and μs', respectively) is fundamental to many applications of light in medicine and biology. We report a handheld fiberoptic probe to determine these coefficients by measuring the diffuse reflectance at multiple source-collector distances, which allows for a larger dynamic range than a single source-collector separation. Diffusion theory and a priori knowledge of the spectral shape of μa and μs' are used in a forward model of the diffuse reflectance. The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo.

© 2010 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 19, 2010
Revised Manuscript: February 18, 2010
Manuscript Accepted: February 19, 2010
Published: March 3, 2010

Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Anthony Kim, Mathieu Roy, Farhan Dadani, and Brian C. Wilson, "A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients," Opt. Express 18, 5580-5594 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-6-5580


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