Optics InfoBase > Virtual Journal for Biomedical Optics > Volume 5 > Issue 7 > Page 5713
Femtosecond protein nanocrystallography—data analysis methods
Richard A. Kirian, Xiaoyu Wang, Uwe Weierstall, Kevin E. Schmidt, John C. H. Spence, Mark Hunter, Petra Fromme, Thomas White, Henry N. Chapman, and James Holton »View Author Affiliations
Richard A. Kirian,1
Xiaoyu Wang,1
Uwe Weierstall,1
Kevin E. Schmidt,1
John C. H. Spence,1,*
Mark Hunter,2
Petra Fromme,2
Thomas White,3
Henry N. Chapman,3,4
and James Holton5,6
1Department of Physics, Arizona State University, Tempe, Arizona 85287 USA
2Department of Biochemistry, Arizona State Unviversity, Tempe, Arizona 85287 USA
3Center for Free Electron Laser Science DESY University of Hamburg, Notkestrasse 85, 22607, Hamburg, Germany
4University of Hamburg, Luruper Chaussee 149, Hamburg 22761, Germany
5Advanced Light Source, Lawrence Berkeley Laboratory, Berkeley, California 94720 USA
6Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 USA
*Corresponding author: spence@asu.edu
Optics Express, Vol. 18, Issue 6, pp. 5713-5723 (2010)
http://dx.doi.org/10.1364/OE.18.005713
View Full Text Article
Enhanced HTML 
Acrobat PDF (590 KB)
Abstract
X-ray diffraction patterns may be obtained from individual submicron protein nanocrystals using a femtosecond pulse from a free-electron X-ray laser. Many “single-shot” patterns are read out every second from a stream of nanocrystals lying in random orientations. The short pulse terminates before significant atomic (or electronic) motion commences, minimizing radiation damage. Simulated patterns for Photosystem I nanocrystals are used to develop a method for recovering structure factors from tens of thousands of snapshot patterns from nanocrystals varying in size, shape and orientation. We determine the number of shots needed for a required accuracy in structure factor measurement and resolution, and investigate the convergence of our Monte-Carlo integration method.
© 2010 OSA
OCIS Codes
(260.1960) Physical optics : Diffraction theory
(290.5840) Scattering : Scattering, molecules
(320.7100) Ultrafast optics : Ultrafast measurements
ToC Category:
X-ray Optics
History
Original Manuscript: December 23, 2009
Revised Manuscript: February 19, 2010
Manuscript Accepted: February 20, 2010
Published: March 5, 2010
Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics
Citation
Richard A. Kirian, Xiaoyu Wang, Uwe Weierstall, Kevin E. Schmidt, John C. H. Spence, Mark Hunter, Petra Fromme, Thomas White, Henry N. Chapman, and James Holton, "Femtosecond protein nanocrystallography—data analysis methods," Opt. Express 18, 5713-5723 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-6-5713
Sort: Author | Year | Journal | Reset
References
- H. N. Chapman, “X-ray imaging beyond the limits,” Nat. Mater. 8(4), 299–301 (2009). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- R. B. G. Ravelli and E. F. Garman, “Radiation damage in macromolecular cryocrystallography,” Curr. Opin. Struct. Biol. 16(5), 624–629 (2006). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- C. Nave and M. A. Hill, “Will reduced radiation damage occur with very small crystals?” J. Synchrotron Radiat. 12(Pt 3), 299–303 (2005). [CrossRef] [PubMed]
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- A. G. W. Leslie, “The integration of macromolecular diffraction data,” Acta Crystallogr. D Biol. Crystallogr. 62(Pt 1), 48–57 (2006). [CrossRef]
- E. J. W. Whittaker, “The polarization factor for inclined-beam photography using crystal-reflected radiation,” Acta Crystallogr. 6(2), 222–223 (1953). [CrossRef]
- S. Bailey and Collaborative Computational Project, Number 4, “The CCP4 suite: programs for protein crystallography,” Acta Crystallogr. D Biol. Crystallogr. 50(Pt 5), 760–763 (1994). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- D. E. Tronrud, “TNT refinement package,” Methods Enzymol. 277, 306–319 (1997). [CrossRef] [PubMed]
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- G. Hura, Advanced Light Source, Lawrence Berkeley Laboratory, Berkeley, Ca., 94720 USA (personal communication, 2009).
- N. T. D. Loh and V. Elser, “Reconstruction algorithm for single-particle diffraction imaging experiments,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(2 Pt 2), 026705 (2009). [CrossRef] [PubMed]
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- J. C. H. Spence, “Diffractive (lensless) imaging,” in Science of Microscopy, P. Hawkes and J. C. H. Spence eds. (Springer 2007), pp. 1196–1227.
- I. Robinson and R. Harder, “Coherent X-ray diffraction imaging of strain at the nanoscale,” Nat. Mater. 8(4), 291–298 (2009). [CrossRef] [PubMed]
Adolph, M.
Andritschke, R.
Bailey, S.
Bajt, S.
Baker, J. G.
Barty, A.
Battistuz, T.
Bauer, C.
Beetz, T.
Benner, W. H.
Berman, H. M.
Betzel, C.
Bhat, T. N.
Bluhm, W. F.
Bogan, M. J.
Bostedt, C.
Bourne, P. E.
Boutet, S.
Burkhardt, K.
Chapman, H. N.
Chiu, E.
Coulibaly, F.
Cui, C.
Cui, C. W.
Dauter, Z.
Denes, P.
Deponte, D.
DePonte, D. P.
Difiore, D.
Doak, R. B.
Doering, D.
Eckart, R.
Edwards, P. C.
Elser, V.
Epp, S.
Fagan, P.
Feng, Z.
Foucar, L.
Frank, M.
Fromme, P.
Fung, R.
Garman, E. F.
Gärtner, K.
Gilliland, G. L.
Glaeser, R. M.
Graafsma, H.
Granzin, J.
Gutmann, S.
Haebel, P. W.
Hajdu, J.
Hälker, O.
Harder, R.
Hartmann, R.
Hau-Riege, S. P.
Head-Gordon, T.
Heinzinger, K.
Hembree, G.
Hembree, G. G.
Henderson, R.
Herrmann, S.
Hill, M. A.
Hinrichs, W.
Hirsemann, H.
Holl, P.
Holton, J. M.
Howells, M. R.
Hunter, M.
Hura, G.
Ikeda, K.
Iype, L.
Jacobsen, C. J.
Jain, S.
Jordan, P.
Kennedy, P.
Kimmel, N.
Kirz, J.
Klukas, O.
Krasniqi, F.
Krauss, N.
Kühnel, K.-U.
Lee, J. Y.
Leitenberger, W.
Leslie, A. G. W.
Lima, E.
Loh, N. T. D.
London, R. A.
Lutz, G.
Maia, F.
Marchesini, S.
Marklund, E.
Marvin, J.
Meidinger, N.
Metcalf, P.
Miao, H.
Miessner, D.
Möller, T.
Mori, H.
Moshammer, R.
Moukhametzianov, R.
Nave, C.
Ourmazd, A.
Padilla, D.
Padmore, H. A.
Pietsch, U.
Pietschner, D.
Porro, M.
Ravelli, R. B. G.
Ravichandran, V.
Reich, C.
Richter, R.
Riot, V.
Robinson, I.
Rogner, M.
Rohner, U.
Rolles, D.
Rudenko, A.
Rupp, D.
Saenger, W.
Sakdinawat, A. E.
Saldin, D. K.
Sayre, D.
Schertler, G. F. X.
Schlichting, I.
Schmidt, K.
Schneider, B.
Schopper, F.
Schröter, C.-D.
Schubert, W. D.
Schulze-Briese, C.
Seibert, M. M.
Serrano-Vega, M. J.
Shaevitz, J. W.
Shapiro, D.
Shapiro, D. A.
Shneerson, V.
Shoeman, R. L.
Soltau, H.
Sorenson, J. M.
Spence, J.
Spence, J. C. H.
Spiller, E.
Starodub, D.
Strüder, L.
Svenda, M.
Szoke, A.
Szöke, A.
Tate, C. G.
Techert, S.
Thamm, C.
Thanki, N.
Tronrud, D. E.
Ullrich, J.
Walder, J. P.
Walenta, A.
Warne, T.
Warner, J.
Weidenspointner, G.
Weierstall, U.
Weissig, H.
Weizeorick, J.
Westbrook, J. D.
Whittaker, E. J. W.
Witt, H. T.
Witt, I.
Woods, B.
Zardecki, C.
Ziegler, A.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- S. Bailey and Collaborative Computational Project, Number 4, “The CCP4 suite: programs for protein crystallography,” Acta Crystallogr. D Biol. Crystallogr. 50(Pt 5), 760–763 (1994). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- H. N. Chapman, “X-ray imaging beyond the limits,” Nat. Mater. 8(4), 299–301 (2009). [CrossRef] [PubMed]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- N. T. D. Loh and V. Elser, “Reconstruction algorithm for single-particle diffraction imaging experiments,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(2 Pt 2), 026705 (2009). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- R. B. G. Ravelli and E. F. Garman, “Radiation damage in macromolecular cryocrystallography,” Curr. Opin. Struct. Biol. 16(5), 624–629 (2006). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- I. Robinson and R. Harder, “Coherent X-ray diffraction imaging of strain at the nanoscale,” Nat. Mater. 8(4), 291–298 (2009). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- C. Nave and M. A. Hill, “Will reduced radiation damage occur with very small crystals?” J. Synchrotron Radiat. 12(Pt 3), 299–303 (2005). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- A. G. W. Leslie, “The integration of macromolecular diffraction data,” Acta Crystallogr. D Biol. Crystallogr. 62(Pt 1), 48–57 (2006). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- N. T. D. Loh and V. Elser, “Reconstruction algorithm for single-particle diffraction imaging experiments,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(2 Pt 2), 026705 (2009). [CrossRef] [PubMed]
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- C. Nave and M. A. Hill, “Will reduced radiation damage occur with very small crystals?” J. Synchrotron Radiat. 12(Pt 3), 299–303 (2005). [CrossRef] [PubMed]
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- R. B. G. Ravelli and E. F. Garman, “Radiation damage in macromolecular cryocrystallography,” Curr. Opin. Struct. Biol. 16(5), 624–629 (2006). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- I. Robinson and R. Harder, “Coherent X-ray diffraction imaging of strain at the nanoscale,” Nat. Mater. 8(4), 291–298 (2009). [CrossRef] [PubMed]
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- D. E. Tronrud, “TNT refinement package,” Methods Enzymol. 277, 306–319 (1997). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- E. J. W. Whittaker, “The polarization factor for inclined-beam photography using crystal-reflected radiation,” Acta Crystallogr. 6(2), 222–223 (1953). [CrossRef]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
Acta Crystallogr.
- E. J. W. Whittaker, “The polarization factor for inclined-beam photography using crystal-reflected radiation,” Acta Crystallogr. 6(2), 222–223 (1953). [CrossRef]
Acta Crystallogr. D Biol. Crystallogr.
- S. Bailey and Collaborative Computational Project, Number 4, “The CCP4 suite: programs for protein crystallography,” Acta Crystallogr. D Biol. Crystallogr. 50(Pt 5), 760–763 (1994). [CrossRef]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- A. G. W. Leslie, “The integration of macromolecular diffraction data,” Acta Crystallogr. D Biol. Crystallogr. 62(Pt 1), 48–57 (2006). [CrossRef]
Biophys. J.
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
Curr. Opin. Struct. Biol.
- R. B. G. Ravelli and E. F. Garman, “Radiation damage in macromolecular cryocrystallography,” Curr. Opin. Struct. Biol. 16(5), 624–629 (2006). [CrossRef] [PubMed]
Exp. Fluids
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
J. Chem. Phys.
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
J. Electron Spectrosc. Relat. Phenom.
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
J. Phys. D Appl. Phys.
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
J. Synchrotron Radiat.
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- C. Nave and M. A. Hill, “Will reduced radiation damage occur with very small crystals?” J. Synchrotron Radiat. 12(Pt 3), 299–303 (2005). [CrossRef] [PubMed]
Methods Enzymol.
- D. E. Tronrud, “TNT refinement package,” Methods Enzymol. 277, 306–319 (1997). [CrossRef] [PubMed]
Nano Lett.
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
Nat. Mater.
- H. N. Chapman, “X-ray imaging beyond the limits,” Nat. Mater. 8(4), 299–301 (2009). [CrossRef] [PubMed]
- I. Robinson and R. Harder, “Coherent X-ray diffraction imaging of strain at the nanoscale,” Nat. Mater. 8(4), 291–298 (2009). [CrossRef] [PubMed]
Nat. Photonics
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
Nat. Phys.
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
Nat. Struct. Biol.
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
Nature
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
Nucl. Instrum. Methods
- L. Strüder, S. Epp, D. Rolles, R. Hartmann, P. Holl, G. Lutz, H. Soltau, R. Eckart, C. Reich, K. Heinzinger, C. Thamm, A. Rudenko, F. Krasniqi, K.-U. Kühnel, C. Bauer, C.-D. Schröter, R. Moshammer, S. Techert, D. Miessner, M. Porro, O. Hälker, N. Meidinger, N. Kimmel, R. Andritschke, F. Schopper, G. Weidenspointner, A. Ziegler, D. Pietschner, S. Herrmann, U. Pietsch, A. Walenta, W. Leitenberger, C. Bostedt, T. Möller, D. Rupp, M. Adolph, H. Graafsma, H. Hirsemann, K. Gärtner, R. Richter, L. Foucar, R. L. Shoeman, I. Schlichting, and J. Ullrich, “Large-format, high-speed, X-ray pnCCDs combined with electron and ion imaging spectrometers in a multipurpose chamber for experiments at 4th generation light sources,” Nucl. Instrum. Methods . in press.
Phys. Chem. Chem. Phys.
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
Phys. Rev. E Stat. Nonlin. Soft Matter Phys.
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- N. T. D. Loh and V. Elser, “Reconstruction algorithm for single-particle diffraction imaging experiments,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(2 Pt 2), 026705 (2009). [CrossRef] [PubMed]
Rev. Sci. Instrum.
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
Other
- G. Hura, Advanced Light Source, Lawrence Berkeley Laboratory, Berkeley, Ca., 94720 USA (personal communication, 2009).
- J. C. H. Spence, “Diffractive (lensless) imaging,” in Science of Microscopy, P. Hawkes and J. C. H. Spence eds. (Springer 2007), pp. 1196–1227.
2009, Denes, Rev. Sci. Instrum.
- P. Denes, D. Doering, H. A. Padmore, J. P. Walder, and J. Weizeorick, “A fast, direct x-ray detection charge-coupled device,” Rev. Sci. Instrum. 80(8), 083302 (2009). [CrossRef] [PubMed]
- H. N. Chapman, “X-ray imaging beyond the limits,” Nat. Mater. 8(4), 299–301 (2009). [CrossRef] [PubMed]
- M. R. Howells, T. Beetz, H. N. Chapman, C. Cui, J. M. Holton, C. J. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. A. Shapiro, J. C. H. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy,” J. Electron Spectrosc. Relat. Phenom. 170(1-3), 4–12 (2009). [CrossRef]
- N. T. D. Loh and V. Elser, “Reconstruction algorithm for single-particle diffraction imaging experiments,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(2 Pt 2), 026705 (2009). [CrossRef] [PubMed]
- R. Fung, V. Shneerson, D. K. Saldin, and A. Ourmazd, “Structure from fleeting illumination of faint spinning obects in flight,” Nat. Phys. 5(1), 64–67 (2009). [CrossRef]
- I. Robinson and R. Harder, “Coherent X-ray diffraction imaging of strain at the nanoscale,” Nat. Mater. 8(4), 291–298 (2009). [CrossRef] [PubMed]
- T. Warne, M. J. Serrano-Vega, J. G. Baker, R. Moukhametzianov, P. C. Edwards, R. Henderson, A. G. W. Leslie, C. G. Tate, and G. F. X. Schertler, “Structure of a beta1-adrenergic G-protein-coupled receptor,” Nature 454(7203), 486–491 (2008). [CrossRef] [PubMed]
- M. J. Bogan, W. H. Benner, S. Boutet, U. Rohner, M. Frank, A. Barty, M. M. Seibert, F. Maia, S. Marchesini, S. Bajt, B. Woods, V. Riot, S. P. Hau-Riege, M. Svenda, E. Marklund, E. Spiller, J. Hajdu, and H. N. Chapman, “Single particle X-ray diffractive imaging,” Nano Lett. 8(1), 310–316 (2008). [CrossRef]
- D. P. DePonte, U. Weierstall, K. Schmidt, J. Warner, D. Starodub, J. C. H. Spence, and R. B. Doak, “Gas dynamic virtual nozzle for generation of microscopic droplet streams,” J. Phys. D Appl. Phys. 41(19), 195505 (2008). [CrossRef]
- U. Weierstall, R. B. Doak, J. C. H. Spence, D. Starodub, D. Shapiro, P. Kennedy, J. Warner, G. G. Hembree, P. Fromme, and H. N. Chapman, “Droplet streams for serial crystallography of proteins,” Exp. Fluids 44(5), 675–689 (2008). [CrossRef]
- D. A. Shapiro, H. N. Chapman, D. Deponte, R. B. Doak, P. Fromme, G. Hembree, M. Hunter, S. Marchesini, K. Schmidt, J. Spence, D. Starodub, and U. Weierstall, “Powder diffraction from a continuous microjet of submicrometer protein crystals,” J. Synchrotron Radiat. 15(Pt 6), 593–599 (2008). [CrossRef] [PubMed]
- S. Marchesini, S. Boutet, A. E. Sakdinawat, M. J. Bogan, S. Bajt, A. Barty, H. N. Chapman, M. Frank, S. P. Hau-Riege, A. Szöke, C. W. Cui, D. A. Shapiro, M. R. Howells, J. C. H. Spence, J. W. Shaevitz, J. Y. Lee, J. Hajdu, and M. M. Seibert, “Massively parallel X-ray holography,” Nat. Photonics 2(9), 560–563 (2008). [CrossRef]
- S. Boutet, M. J. Bogan, A. Barty, M. Frank, W. H. Benner, S. Marchesini, M. M. Seibert, J. Hajdu, and H. N. Chapman, “Ultrafast soft x-ray scattering and reference-enhanced diffractive imaging of weakly scattering nanoparticles,” J. Electron Spectrosc. Relat. Phenom. 166–167, 65–73 (2008). [CrossRef]
- F. Coulibaly, E. Chiu, K. Ikeda, S. Gutmann, P. W. Haebel, C. Schulze-Briese, H. Mori, and P. Metcalf, “The molecular organization of cypovirus polyhedra,” Nature 446(7131), 97–101 (2007). [CrossRef] [PubMed]
- R. B. G. Ravelli and E. F. Garman, “Radiation damage in macromolecular cryocrystallography,” Curr. Opin. Struct. Biol. 16(5), 624–629 (2006). [CrossRef] [PubMed]
- A. G. W. Leslie, “The integration of macromolecular diffraction data,” Acta Crystallogr. D Biol. Crystallogr. 62(Pt 1), 48–57 (2006). [CrossRef]
- C. Nave and M. A. Hill, “Will reduced radiation damage occur with very small crystals?” J. Synchrotron Radiat. 12(Pt 3), 299–303 (2005). [CrossRef] [PubMed]
- S. P. Hau-Riege, R. A. London, and A. Szoke, “Dynamics of biological molecules irradiated by short x-ray pulses,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69(5 Pt 1), 051906 (2004). [CrossRef] [PubMed]
- H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki, “The protein data bank,” Acta Crystallogr. D Biol. Crystallogr. 58(Pt 6 No 1), 899–907 (2002). [CrossRef] [PubMed]
- P. Jordan, P. Fromme, H. T. Witt, O. Klukas, W. Saenger, and N. Krauss, “Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution,” Nature 411(6840), 909–917 (2001). [CrossRef] [PubMed]
- G. Hura, J. M. Sorenson, R. M. Glaeser, and T. Head-Gordon, “A high-quality x-ray scattering experiment on liquid water at ambient conditions,” J. Chem. Phys. 113(20), 9140–9148 (2000). [CrossRef]
- D. E. Tronrud, “TNT refinement package,” Methods Enzymol. 277, 306–319 (1997). [CrossRef] [PubMed]
- N. Krauss, W. D. Schubert, O. Klukas, P. Fromme, H. T. Witt, and W. Saenger, “Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system,” Nat. Struct. Biol. 3(11), 965–973 (1996). [CrossRef] [PubMed]
- H. T. Witt, I. Witt, N. Krauss, W. Hinrichs, P. Fromme, and W. Saenger, “Crystals and structure of photosystem-1,” Biophys. J. 66, A2–A3 (1994).
- S. Bailey and Collaborative Computational Project, Number 4, “The CCP4 suite: programs for protein crystallography,” Acta Crystallogr. D Biol. Crystallogr. 50(Pt 5), 760–763 (1994). [CrossRef]
- I. Witt, H. T. Witt, D. Difiore, M. Rogner, W. Hinrichs, W. Saenger, J. Granzin, C. Betzel, and Z. Dauter, ““X-ray characterization of single-crystals of the reaction center-I of water-splitting photosynthesis,” Ber. Bunsen-Ges,” Phys. Chem. Chem. Phys. 92, 1503–1506 (1988).
- E. J. W. Whittaker, “The polarization factor for inclined-beam photography using crystal-reflected radiation,” Acta Crystallogr. 6(2), 222–223 (1953). [CrossRef]
Cited By |
 Alert me when this paper is cited |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.
Related Journal Articles 
- Isotropic scattering by penetrable cylinders (JOSAA)
- Average characteristics of partially coherent electromagnetic beams (JOSAA)
- Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals (OE)
- In-plane rotation classification for coherent X-ray imaging of single biomolecules (OE)
- Unsupervised classification of single-particle X-ray diffraction snapshots by spectral clustering (OE)
Related Conference Papers
- High sensitive optical sampling oscilloscope simultaneous coverage of both C and L bands
- Feasible Light Fields in Three-Dimensional Space
- Feasible Light Fields in Three-Dimensional Space
- Interferometric Characterization of Deep Ultraviolet Femtosecond Pulses by Multi-Photon Ionization/Mass Spectrometer
- Dispersion Behavior of Surface Waves on Metal Wires in the Terahertz Frequency Range
« Previous Article | Next Article »
OSA is a member of 
For optimal display we recommend the following web browsers:
- Firefox 11+
- Google Chrome 17+
- Internet Explorer 9+
- Safari 5+