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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 7 — Apr. 26, 2010

Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering

Suchin Trirongjitmoah, Toshihiro Sakurai, Kazuya Iinaga, Hitoshi Chiba, and Koichi Shimizu  »View Author Affiliations


Optics Express, Vol. 18, Issue 6, pp. 6315-6326 (2010)
http://dx.doi.org/10.1364/OE.18.006315


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Abstract

Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements.

© 2010 OSA

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(290.5850) Scattering : Scattering, particles

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 30, 2009
Revised Manuscript: February 12, 2010
Manuscript Accepted: February 22, 2010
Published: March 12, 2010

Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Suchin Trirongjitmoah, Toshihiro Sakurai, Kazuya Iinaga, Hitoshi Chiba, and Koichi Shimizu, "Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering," Opt. Express 18, 6315-6326 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-6-6315


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