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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 8 — Jun. 8, 2010

Fiber probe based microfluidic raman spectroscopy

P. C. Ashok, G. P. Singh, K. M. Tan, and K. Dholakia  »View Author Affiliations


Optics Express, Vol. 18, Issue 8, pp. 7642-7649 (2010)
http://dx.doi.org/10.1364/OE.18.007642


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Abstract

We report a novel fiber probe based Raman detection system on a microfluidic platform where a split Raman probe is directly embedded into a polydimethylsiloxane (PDMS) chip. In contrast to previous Raman detection schemes in microfluidics, probe based detection offers reduced background and portability. Compared to conventional backscattering probe designs, the split fiber probe we used in this system, results in a reduced size and offers flexibility to modify the collection geometry to minimize the background generated by the fibers. Also our microfluidic chip design enables us to obtain an alignment free system. As a proof of concept we demonstrate the sensitivity of the device for urea detection at relevant human physiological levels with a low acquisition time. The development of this system on a microfluidic platform means portable, lab on a chip devices for biological analyte detection and environmental sensing using Raman spectroscopy are now within reach.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 16, 2010
Revised Manuscript: March 12, 2010
Manuscript Accepted: March 26, 2010
Published: March 29, 2010

Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics

Citation
P. C. Ashok, G. P. Singh, K. M. Tan, and K. Dholakia, "Fiber probe based microfluidic raman spectroscopy," Opt. Express 18, 7642-7649 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-8-7642


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