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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 8 — Jun. 8, 2010

Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins

Torre M. Bydlon, Stephanie A. Kennedy, Lisa M. Richards, J. Quincy Brown, Bing Yu, Marlee K. Junker, Jennifer Gallagher, Joseph Geradts, Lee G. Wilke, and Nimmi Ramanujam  »View Author Affiliations


Optics Express, Vol. 18, Issue 8, pp. 8058-8076 (2010)
http://dx.doi.org/10.1364/OE.18.008058


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Abstract

As many as 20-70% of patients undergoing breast conserving surgery require repeat surgeries due to a close or positive surgical margin diagnosed post-operatively [1]. Currently there are no widely accepted tools for intra-operative margin assessment which is a significant unmet clinical need. Our group has developed a first-generation optical visible spectral imaging platform to image the molecular composition of breast tumor margins and has tested it clinically in 48 patients in a previously published study [2]. The goal of this paper is to report on the performance metrics of the system and compare it to clinical criteria for intra-operative tumor margin assessment. The system was found to have an average signal to noise ratio (SNR) >100 and <15% error in the extraction of optical properties indicating that there is sufficient SNR to leverage the differences in optical properties between negative and close/positive margins. The probe had a sensing depth of 0.5-2.2 mm over the wavelength range of 450-600 nm which is consistent with the pathologic criterion for clear margins of 0-2 mm. There was <1% cross-talk between adjacent channels of the multi-channel probe which shows that multiple sites can be measured simultaneously with negligible cross-talk between adjacent sites. Lastly, the system and measurement procedure were found to be reproducible when evaluated with repeated measures, with a low coefficient of variation (<0.11). The only aspect of the system not optimized for intra-operative use was the imaging time. The manuscript includes a discussion of how the speed of the system can be improved to work within the time constraints of an intra-operative setting.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.0230) Optical devices : Optical devices
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 21, 2009
Revised Manuscript: March 19, 2010
Manuscript Accepted: March 20, 2010
Published: April 1, 2010

Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Torre M. Bydlon, Stephanie A. Kennedy, Lisa M. Richards, J. Quincy Brown, Bing Yu, Marlee K. Junker, Jennifer Gallagher, Joseph Geradts, Lee G. Wilke, and Nimmi Ramanujam, "Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins," Opt. Express 18, 8058-8076 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-8-8058


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