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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 9 — Jul. 6, 2010

Multispectral photoacoustic coded excitation imaging using unipolar orthogonal Golay codes

Martin P. Mienkina, Claus-Stefan Friedrich, Nils C. Gerhardt, Martin F. Beckmann, Martin F. Schiffner, Martin R. Hofmann, and Georg Schmitz  »View Author Affiliations


Optics Express, Vol. 18, Issue 9, pp. 9076-9087 (2010)
http://dx.doi.org/10.1364/OE.18.009076


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Abstract

We present a method to speed up the acquisition of multispectral photoacoustic data sets by using unipolar orthogonal Golay codes as excitation sequences for the irradiation system. Multispectral photoacoustic coded excitation (MS-PACE) allows acquiring photoacoustic data sets for two irradiation wavelengths simultaneously and separating them afterwards, thus improving the SNR or speeding up the measurement. We derive an analytical estimation of the SNR improvement using MS-PACE compared to time equivalent averaging. We demonstrate the feasibility of the method by successfully imaging a phantom composed of two dyes using unipolar orthogonal Golay codes as excitation sequence for two high power laser diodes operating at two different wavelengths. The experimental results show very good agreement with the theoretical predictions.

© 2010 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(140.2020) Lasers and laser optics : Diode lasers
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Imaging Systems

History
Original Manuscript: February 9, 2010
Revised Manuscript: March 19, 2010
Manuscript Accepted: March 20, 2010
Published: April 15, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Martin P. Mienkina, Claus-Stefan Friedrich, Nils C. Gerhardt, Martin F. Beckmann, Martin F. Schiffner, Martin R. Hofmann, and Georg Schmitz, "Multispectral photoacoustic coded excitation imaging using unipolar orthogonal Golay codes," Opt. Express 18, 9076-9087 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-9-9076


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