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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 9 — Oct. 3, 2011

Simultaneous automatic arteries-veins separation and cerebral blood flow imaging with single-wavelength laser speckle imaging

Nengyun Feng, Jianjun Qiu, Pengcheng Li, Xiaoli Sun, Cui Yin, Weihua Luo, Shangbin Chen, and Qingming Luo  »View Author Affiliations


Optics Express, Vol. 19, Issue 17, pp. 15777-15791 (2011)
http://dx.doi.org/10.1364/OE.19.015777


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Abstract

Automatic separation of arteries and veins in optical cerebral cortex images is important in clinical practice and preclinical study. In this paper, a simple but effective automatic artery-vein separation method which utilizes single-wavelength coherent illumination is presented. This method is based on the relative temporal minimum reflectance analysis of laser speckle images. The validation is demonstrated with both theoretic simulations and experimental results applied to the rat cortex. Moreover, this method can be combined with laser speckle contrast analysis so that the artery-vein separation and blood flow imaging can be simultaneously obtained using the same raw laser speckle images data to enable more accurate analysis of changes of cerebral blood flow within different tissue compartments during functional activation, disease dynamic, and neurosurgery, which may broaden the applications of laser speckle imaging in biology and medicine.

© 2011 OSA

OCIS Codes
(100.2960) Image processing : Image analysis
(110.6150) Imaging systems : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 9, 2011
Revised Manuscript: July 12, 2011
Manuscript Accepted: July 26, 2011
Published: August 3, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Nengyun Feng, Jianjun Qiu, Pengcheng Li, Xiaoli Sun, Cui Yin, Weihua Luo, Shangbin Chen, and Qingming Luo, "Simultaneous automatic arteries-veins separation and cerebral blood flow imaging with single-wavelength laser speckle imaging," Opt. Express 19, 15777-15791 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-19-17-15777


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