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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 9 — Oct. 3, 2011

Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities

Jiangang Zhu, Şahin Kaya Özdemir, Lina He, Da-Ren Chen, and Lan Yang  »View Author Affiliations

Optics Express, Vol. 19, Issue 17, pp. 16195-16206 (2011)

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Detecting and characterizing single nanoparticles and airborne viruses are of paramount importance for disease control and diagnosis, for environmental monitoring, and for understanding size dependent properties of nanoparticles for developing innovative products. Although single particle and virus detection have been demonstrated in various platforms, single-shot size measurement of each detected particle has remained a significant challenge. Here, we present a nanoparticle size spectrometry scheme for label-free, real-time and continuous detection and sizing of single Influenza A virions, polystyrene and gold nanoparticles using split whispering-gallery-modes (WGMs) in an ultra-high-Q resonator. We show that the size of each particle and virion can be measured as they continuously bind to the resonator one-by-one, eliminating the need for ensemble measurements, stochastic analysis or imaging techniques employed in previous works. Moreover, we show that our scheme has the ability to identify the components of particle mixtures.

© 2011 OSA

OCIS Codes
(130.6010) Integrated optics : Sensors
(140.4780) Lasers and laser optics : Optical resonators
(140.3945) Lasers and laser optics : Microcavities
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:

Original Manuscript: June 2, 2011
Revised Manuscript: July 18, 2011
Manuscript Accepted: July 19, 2011
Published: August 9, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Jiangang Zhu, Şahin Kaya Özdemir, Lina He, Da-Ren Chen, and Lan Yang, "Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities," Opt. Express 19, 16195-16206 (2011)

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