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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 1 — Jan. 4, 2012

Full range characterization of the Raman spectra of organs in a murine model

Naiyan Huang, Michael Short, Jianhua Zhao, Hequn Wang, Harvey Lui, Mladen Korbelik, and Haishan Zeng  »View Author Affiliations


Optics Express, Vol. 19, Issue 23, pp. 22892-22909 (2011)
http://dx.doi.org/10.1364/OE.19.022892


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Abstract

Raman spectroscopy is a minimally-invasive optical technique with great potential for in vivo cancer detection and disease diagnosis. However, there is no systematic study of the Raman spectra from different organs to date. We measured and characterized the Raman spectra eighteen naïve mouse organs in a broad frequency range of 700 to 3100 cm−1. The peaks of generic proteins and lipids appeared in Raman spectra of all organs. Some organs like bone, teeth, brain and lung had unique Raman peaks. The autofluorescence was strong in liver, spleen, heart, and kidney. These results suggest that organ specific Raman probe design and specific data processing strategies are required in order to get the most useful information.

© 2011 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 8, 2011
Revised Manuscript: October 6, 2011
Manuscript Accepted: October 6, 2011
Published: October 27, 2011

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Naiyan Huang, Michael Short, Jianhua Zhao, Hequn Wang, Harvey Lui, Mladen Korbelik, and Haishan Zeng, "Full range characterization of the Raman spectra of organs in a murine model," Opt. Express 19, 22892-22909 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-19-23-22892


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