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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 1 — Jan. 4, 2012

On-chip modulation of evanescent illumination and live-cell imaging with polymer waveguides

Björn Agnarsson, Asta B. Jonsdottir, Nina B. Arnfinnsdottir, and Kristjan Leosson  »View Author Affiliations


Optics Express, Vol. 19, Issue 23, pp. 22929-22935 (2011)
http://dx.doi.org/10.1364/OE.19.022929


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Abstract

Imaging of live cells was carried out using evanescent-wave excitation on a polymer waveguide chip. Integrated waveguide-based interferometric light modulators were fabricated in order to demonstrate on-chip control of excitation light, e.g., for time-lapse fluorescence microscopy. When combined with a sensitive high-resolution imaging system, the integrated waveguide-excitation platform provides an ideal method of near-surface studies of live cells, where photobleaching and/or phototoxicity effects are of critical concern.

© 2011 OSA

OCIS Codes
(130.0130) Integrated optics : Integrated optics
(180.2520) Microscopy : Fluorescence microscopy
(230.7390) Optical devices : Waveguides, planar
(250.5460) Optoelectronics : Polymer waveguides
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 2, 2011
Revised Manuscript: September 30, 2011
Manuscript Accepted: October 11, 2011
Published: October 27, 2011

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Björn Agnarsson, Asta B. Jonsdottir, Nina B. Arnfinnsdottir, and Kristjan Leosson, "On-chip modulation of evanescent illumination and live-cell imaging with polymer waveguides," Opt. Express 19, 22929-22935 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-19-23-22929


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