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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 4 — May. 4, 2011

Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

Chi-Hsiang Lien, Wen-Shuo Kuo, Keng-Chi Cho, Chun-Yu Lin, Yuan-Deng Su, Lynn L. H. Huang, Paul J. Campagnola, Chen Yuan Dong, and Shean-Jen Chen  »View Author Affiliations

Optics Express, Vol. 19, Issue 7, pp. 6260-6268 (2011)

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In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

© 2011 OSA

OCIS Codes
(120.4610) Instrumentation, measurement, and metrology : Optical fabrication
(190.4180) Nonlinear optics : Multiphoton processes
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Optics at Surfaces

Original Manuscript: January 12, 2011
Revised Manuscript: March 8, 2011
Manuscript Accepted: March 11, 2011
Published: March 18, 2011

Virtual Issues
Vol. 6, Iss. 4 Virtual Journal for Biomedical Optics

Chi-Hsiang Lien, Wen-Shuo Kuo, Keng-Chi Cho, Chun-Yu Lin, Yuan-Deng Su, Lynn L. H. Huang, Paul J. Campagnola, Chen Yuan Dong, and Shean-Jen Chen, "Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry," Opt. Express 19, 6260-6268 (2011)

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