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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

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  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 3 — Feb. 29, 2012

Hybrid feature selection and SVM-based classification for mouse skin precancerous stages diagnosis from bimodal spectroscopy

F. Abdat, M. Amouroux, Y. Guermeur, and W. Blondel  »View Author Affiliations


Optics Express, Vol. 20, Issue 1, pp. 228-244 (2012)
http://dx.doi.org/10.1364/OE.20.000228


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Abstract

This paper deals with multi-class classification of skin pre-cancerous stages based on bimodal spectroscopic features combining spatially resolved AutoFluorescence (AF) and Diffuse Reflectance (DR) measurements. A new hybrid method to extract and select features is presented. It is based on Discrete Cosine Transform (DCT) applied to AF spectra and on Mutual Information (MI) applied to DR spectra. The classification is performed by means of a multi-class SVM: the M-SVM2. Its performance is compared with the one of the One-Versus-All (OVA) decomposition method involving bi-class SVMs as base classifiers. The results of this study show that bimodality and the choice of an adequate spatial resolution allow for a significant increase in diagnostic accuracy. This accuracy can get as high as 81.7% when combining different distances in the case of bimodality.

© 2011 OSA

OCIS Codes
(070.4790) Fourier optics and signal processing : Spectrum analysis
(070.5010) Fourier optics and signal processing : Pattern recognition
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(070.2025) Fourier optics and signal processing : Discrete optical signal processing

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 17, 2011
Revised Manuscript: November 21, 2011
Manuscript Accepted: November 24, 2011
Published: December 20, 2011

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Citation
F. Abdat, M. Amouroux, Y. Guermeur, and W. Blondel, "Hybrid feature selection and SVM-based classification for mouse skin precancerous stages diagnosis from bimodal spectroscopy," Opt. Express 20, 228-244 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-1-228


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