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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 3 — Feb. 29, 2012

High-resolution biosensor based on localized surface plasmons

Marek Piliarik, Hana Šípová, Pavel Kvasnička, Nicolle Galler, Joachim R. Krenn, and Jiří Homola  »View Author Affiliations

Optics Express, Vol. 20, Issue 1, pp. 672-680 (2012)

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We report on a new biosensor with localized surface plasmons (LSP) based on an array of gold nanorods and the total internal reflection imaging in polarization contrast. The sensitivity of the new biosensor is characterized and a model detection of DNA hybridization is carried out. The results are compared with a reference experiment using a conventional high-resolution surface plasmon resonance (SPR) biosensor. We show that the LSP-based biosensor delivers the same performance as the SPR system while involving significantly lower surface densities of interacting molecules. We demonstrate a limit of detection of 100 pM and a surface density resolution of only 35 fg×mm−2 that corresponds to less than one DNA molecule per nanoparticle on average.

© 2011 OSA

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:

Original Manuscript: November 2, 2011
Revised Manuscript: December 5, 2011
Manuscript Accepted: December 10, 2011
Published: December 23, 2011

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Marek Piliarik, Hana Šípová, Pavel Kvasnička, Nicolle Galler, Joachim R. Krenn, and Jiří Homola, "High-resolution biosensor based on localized surface plasmons," Opt. Express 20, 672-680 (2012)

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