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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 7 — Jun. 25, 2012

Radioluminescent nanophosphors enable multiplexed small-animal imaging

Colin M Carpenter, Conroy Sun, Guillem Pratx, Hongguang Liu, Zhen Cheng, and Lei Xing  »View Author Affiliations

Optics Express, Vol. 20, Issue 11, pp. 11598-11604 (2012)

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We demonstrate the ability to image multiple nanoparticle-based contrast agents simultaneously using a nanophosphor platform excited by either radiopharmaceutical or X-ray irradiation. These radioluminescent nanoparticles emit optical light at unique wavelengths depending on their lanthanide dopant, enabling multiplexed imaging. This study demonstrates the separation of two distinct nanophosphor contrast agents in gelatin phantoms with a recovered phosphor separation correlation of −0.98. The ability to distinguish the two nanophosphors and a Cerenkov component is then demonstrated in a small animal phantom. Combined with the high-resolution potential of low-scattering X-ray excitation, this imaging technique may be a promising method to probe molecular processes in living organisms.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(110.4234) Imaging systems : Multispectral and hyperspectral imaging
(160.4236) Materials : Nanomaterials

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 7, 2012
Revised Manuscript: April 6, 2012
Manuscript Accepted: April 7, 2012
Published: May 7, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

Colin M Carpenter, Conroy Sun, Guillem Pratx, Hongguang Liu, Zhen Cheng, and Lei Xing, "Radioluminescent nanophosphors enable multiplexed small-animal imaging," Opt. Express 20, 11598-11604 (2012)

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