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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 10 — Oct. 5, 2012

High numerical aperture reflection mode coherent diffraction microscopy using off-axis apertured illumination

Dennis F. Gardner, Bosheng Zhang, Matthew D. Seaberg, Leigh S. Martin, Daniel E. Adams, Farhad Salmassi, Eric Gullikson, Henry Kapteyn, and Margaret Murnane  »View Author Affiliations

Optics Express, Vol. 20, Issue 17, pp. 19050-19059 (2012)

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We extend coherent diffraction imaging (CDI) to a high numerical aperture reflection mode geometry for the first time. We derive a coordinate transform that allows us to rewrite the recorded far-field scatter pattern from a tilted object as a uniformly spaced Fourier transform. Using this approach, FFTs in standard iterative phase retrieval algorithms can be used to significantly speed up the image reconstruction times. Moreover, we avoid the isolated sample requirement by imaging a pinhole onto the specimen, in a technique termed apertured illumination CDI. By combining the new coordinate transformation with apertured illumination CDI, we demonstrate rapid high numerical aperture imaging of samples illuminated by visible laser light. Finally, we demonstrate future promise for this technique by using high harmonic beams for high numerical aperture reflection mode imaging.

© 2012 OSA

OCIS Codes
(100.5070) Image processing : Phase retrieval
(190.2620) Nonlinear optics : Harmonic generation and mixing
(340.7460) X-ray optics : X-ray microscopy
(340.7480) X-ray optics : X-rays, soft x-rays, extreme ultraviolet (EUV)

ToC Category:
Image Processing

Original Manuscript: June 21, 2012
Revised Manuscript: July 22, 2012
Manuscript Accepted: July 23, 2012
Published: August 3, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Dennis F. Gardner, Bosheng Zhang, Matthew D. Seaberg, Leigh S. Martin, Daniel E. Adams, Farhad Salmassi, Eric Gullikson, Henry Kapteyn, and Margaret Murnane, "High numerical aperture reflection mode coherent diffraction microscopy using off-axis apertured illumination," Opt. Express 20, 19050-19059 (2012)

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