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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 10 — Oct. 5, 2012

Highly sensitive biosensor based on UV-imprinted layered polymeric–inorganic composite waveguides

Meng Wang, Jussi Hiltunen, Christina Liedert, Stuart Pearce, Martin Charlton, Leena Hakalahti, Pentti Karioja, and Risto Myllylä  »View Author Affiliations

Optics Express, Vol. 20, Issue 18, pp. 20309-20317 (2012)

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An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10−7 RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.

© 2012 OSA

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(130.5460) Integrated optics : Polymer waveguides

ToC Category:

Original Manuscript: May 11, 2012
Revised Manuscript: August 11, 2012
Manuscript Accepted: August 15, 2012
Published: August 20, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Meng Wang, Jussi Hiltunen, Christina Liedert, Stuart Pearce, Martin Charlton, Leena Hakalahti, Pentti Karioja, and Risto Myllylä, "Highly sensitive biosensor based on UV-imprinted layered polymeric–inorganic composite waveguides," Opt. Express 20, 20309-20317 (2012)

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