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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 10 — Oct. 5, 2012

Hierarchical Bayesian estimation improves depth accuracy and spatial resolution of diffuse optical tomography

Takeaki Shimokawa, Takashi Kosaka, Okito Yamashita, Nobuo Hiroe, Takashi Amita, Yoshihiro Inoue, and Masa-aki Sato  »View Author Affiliations

Optics Express, Vol. 20, Issue 18, pp. 20427-20446 (2012)

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High-density diffuse optical tomography (HD-DOT) is an emerging technique for visualizing the internal state of biological tissues. The large number of overlapping measurement channels due to the use of high-density probe arrays permits the reconstruction of the internal optical properties, even with a reflectance-only measurement. However, accurate three-dimensional reconstruction is still a challenging problem. First, the exponentially decaying sensitivity causes a systematic depth-localization error. Second, the nature of diffusive light makes the image blurred. In this paper, we propose a three-dimensional reconstruction method that overcomes these two problems by introducing sensitivity-normalized regularization and sparsity into the hierarchical Bayesian method. Phantom experiments were performed to validate the proposed method under three conditions of probe interval: 26 mm, 18.4 mm, and 13 mm. We found that two absorbers with distances shorter than the probe interval could be discriminated under the high-density conditions of 18.4-mm and 13-mm intervals. This discrimination ability was possible even if the depths of the two absorbers were different from each other. These results show the high spatial resolution of the proposed method in both depth and horizontal directions.

© 2012 OSA

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(100.3190) Image processing : Inverse problems
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Image Processing

Original Manuscript: April 9, 2012
Revised Manuscript: August 12, 2012
Manuscript Accepted: August 15, 2012
Published: August 21, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Takeaki Shimokawa, Takashi Kosaka, Okito Yamashita, Nobuo Hiroe, Takashi Amita, Yoshihiro Inoue, and Masa-aki Sato, "Hierarchical Bayesian estimation improves depth accuracy and spatial resolution of diffuse optical tomography," Opt. Express 20, 20427-20446 (2012)

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