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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 11 — Oct. 31, 2012

Lens-less surface second harmonic imaging

Krystal L. Sly, Trang T. Nguyen, and John C. Conboy  »View Author Affiliations


Optics Express, Vol. 20, Issue 20, pp. 21953-21967 (2012)
http://dx.doi.org/10.1364/OE.20.021953


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Abstract

Lens-less surface second harmonic generation imaging (SSHGI) is used to image an SHG active molecule, (S)-( + )-1,1’-bi-2-naphthol (SBN), incorporated into a lipid bilayer patterned with the 1951 United States Air Force resolution test target. Data show the coherent plane-wave nature of SHG allows direct imaging without the aid of a lens system. Lens-less SSHGI readily resolves line-widths as small as 223 μm at an object-image distance of 7.6 cm and line-widths of 397 μm at distances as far as 30 cm. Lens-less SSHGI simplifies the detection method, raises photon collection efficiency, and expands the field-of-view. These advantages allow greater throughput and make lens-less SSHGI a potentially valuable detection method for biosensors and medical diagnostics.

© 2012 OSA

OCIS Codes
(110.1650) Imaging systems : Coherence imaging
(110.2970) Imaging systems : Image detection systems
(190.4350) Nonlinear optics : Nonlinear optics at surfaces
(240.6490) Optics at surfaces : Spectroscopy, surface

ToC Category:
Imaging Systems

History
Original Manuscript: July 17, 2012
Revised Manuscript: September 6, 2012
Manuscript Accepted: September 7, 2012
Published: September 11, 2012

Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Krystal L. Sly, Trang T. Nguyen, and John C. Conboy, "Lens-less surface second harmonic imaging," Opt. Express 20, 21953-21967 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-20-21953


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