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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 11 — Oct. 31, 2012

Three-dimensional optoacoustic tomography at video rate

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky  »View Author Affiliations


Optics Express, Vol. 20, Issue 20, pp. 22712-22719 (2012)
http://dx.doi.org/10.1364/OE.20.022712


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Abstract

Using optoacoustic excitation, a complete volumetric tomographic data sets from the imaged object can in principle be generated with a single interrogating laser pulse. Thus, optoacoustic imaging intrinsically has the potential for fast three-dimensional imaging. We have developed a system capable of acquiring volumetric optoacoustic data in real time and showcase in this work the undocumented capacity to generate high resolution three-dimensional optoacoustic images at a rate of 10Hz, currently mainly limited by the pulse repetition rate of the excitation laser.

© 2012 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Imaging Systems

History
Original Manuscript: July 5, 2012
Revised Manuscript: August 28, 2012
Manuscript Accepted: August 28, 2012
Published: September 19, 2012

Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Citation
A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, "Three-dimensional optoacoustic tomography at video rate," Opt. Express 20, 22712-22719 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-20-22712


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References

  1. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009). [CrossRef] [PubMed]
  2. M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum.77(4), 041101 (2006). [CrossRef]
  3. V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods7(8), 603–614 (2010). [CrossRef] [PubMed]
  4. V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev.110(5), 2783–2794 (2010). [CrossRef] [PubMed]
  5. L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008). [CrossRef] [PubMed]
  6. L. V. Wang, “Tutorial on photoacoustic microscopy and computed tomography,” IEEE J. Sel. Top. Quantum Electron.14(1), 171–179 (2008). [CrossRef]
  7. D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011). [CrossRef] [PubMed]
  8. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express17(24), 21414–21426 (2009). [CrossRef] [PubMed]
  9. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics3(7), 412–417 (2009). [CrossRef]
  10. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett.32(19), 2891–2893 (2007). [CrossRef] [PubMed]
  11. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol.54(9), 2769–2777 (2009). [CrossRef] [PubMed]
  12. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express17(13), 10489–10498 (2009). [CrossRef] [PubMed]
  13. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009). [CrossRef] [PubMed]
  14. B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol.49(7), 1339–1346 (2004). [CrossRef] [PubMed]
  15. A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett.35(14), 2475–2477 (2010). [CrossRef] [PubMed]
  16. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010). [CrossRef] [PubMed]
  17. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009). [CrossRef] [PubMed]
  18. P. Ephrat, M. Roumeliotis, F. S. Prato, and J. J. L. Carson, “Four-dimensional photoacoustic imaging of moving targets,” Opt. Express16(26), 21570–21581 (2008). [CrossRef] [PubMed]
  19. X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging30(2), 401–408 (2011). [CrossRef] [PubMed]
  20. J. A. Jensen, “Field: A program for simulating ultrasound systems,” Med. Biol. Eng. Comput.34, 351–353 (1996). [PubMed]
  21. J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control39(2), 262–267 (1992). [CrossRef] [PubMed]
  22. M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys.67(5), 056605 (2003). [CrossRef] [PubMed]
  23. S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics20(16), 2857–2859 (2004). [CrossRef] [PubMed]

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