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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 6 — May. 25, 2012

Simultaneous measurement of quality factor and wavelength shift by phase shift microcavity ring down spectroscopy

M. Imran Cheema, Simin Mehrabani, Ahmad A. Hayat, Yves-Alain Peter, Andrea M. Armani, and Andrew G. Kirk  »View Author Affiliations


Optics Express, Vol. 20, Issue 8, pp. 9090-9098 (2012)
http://dx.doi.org/10.1364/OE.20.009090


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Abstract

Optical resonant microcavities with ultra high quality factors are widely used for biosensing. Until now, the primary method of detection has been based upon tracking the resonant wavelength shift as a function of biodetection events. One of the sources of noise in all resonant-wavelength shift measurements is the noise due to intensity fluctuations of the laser source. An alternative approach is to track the change in the quality factor of the optical cavity by using phase shift cavity ring down spectroscopy, a technique which is insensitive to the intensity fluctuations of the laser source. Here, using biotinylated microtoroid resonant cavities, we show simultaneous measurement of the quality factor and the wavelength shift by using phase shift cavity ring down spectroscopy. These measurements were performed for disassociation phase of biotin-streptavidin reaction. We found that the disassociation curves are in good agreement with the previously published results. Hence, we demonstrate not only the application of phase shift cavity ring down spectroscopy to microcavities in the liquid phase but also simultaneous measurement of the quality factor and the wavelength shift for the microcavity biosensors in the application of kinetics measurements.

© 2012 OSA

OCIS Codes
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(280.1545) Remote sensing and sensors : Chemical analysis
(140.3945) Lasers and laser optics : Microcavities
(140.3948) Lasers and laser optics : Microcavity devices
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: March 2, 2012
Revised Manuscript: March 23, 2012
Manuscript Accepted: March 27, 2012
Published: April 3, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
M. Imran Cheema, Simin Mehrabani, Ahmad A. Hayat, Yves-Alain Peter, Andrea M. Armani, and Andrew G. Kirk, "Simultaneous measurement of quality factor and wavelength shift by phase shift microcavity ring down spectroscopy," Opt. Express 20, 9090-9098 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-8-9090


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