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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 2 — Mar. 4, 2013

Recovering fluorophore location and orientation from lifetimes

N. Irishina, M. Moscoso, and R. Carminati  »View Author Affiliations


Optics Express, Vol. 21, Issue 1, pp. 421-430 (2013)
http://dx.doi.org/10.1364/OE.21.000421


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Abstract

In this paper, we study the possibility of using lifetime data to estimate the position and orientation of a fluorescent dipole source within a disordered medium. The vector Foldy-Lax equations are employed to calculate the interaction between the fluorescent source and the scatterers that are modeled as point-scatterers. The numerical experiments demonstrate that if good prior knowledge about the positions of the scatterers is available, the position and orientation of the dipole source can be retrieved from its lifetime data with precision. If there is uncertainty about the positions of the scatterers, the dipole source position can be estimated within the same level of uncertainty.

© 2013 OSA

OCIS Codes
(260.2510) Physical optics : Fluorescence
(290.3200) Scattering : Inverse scattering

ToC Category:
Scattering

History
Original Manuscript: September 18, 2012
Revised Manuscript: November 15, 2012
Manuscript Accepted: November 16, 2012
Published: January 4, 2013

Virtual Issues
Vol. 8, Iss. 2 Virtual Journal for Biomedical Optics

Citation
N. Irishina, M. Moscoso, and R. Carminati, "Recovering fluorophore location and orientation from lifetimes," Opt. Express 21, 421-430 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-1-421


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