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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 6 — Jun. 27, 2013

Wide-field computational color imaging using pixel super-resolved on-chip microscopy

Alon Greenbaum, Alborz Feizi, Najva Akbari, and Aydogan Ozcan  »View Author Affiliations

Optics Express, Vol. 21, Issue 10, pp. 12469-12483 (2013)

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Lens-free holographic on-chip imaging is an emerging approach that offers both wide field-of-view (FOV) and high spatial resolution in a cost-effective and compact design using source shifting based pixel super-resolution. However, color imaging has remained relatively immature for lens-free on-chip imaging, since a ‘rainbow’ like color artifact appears in reconstructed holographic images. To provide a solution for pixel super-resolved color imaging on a chip, here we introduce and compare the performances of two computational methods based on (1) YUV color space averaging, and (2) Dijkstra’s shortest path, both of which eliminate color artifacts in reconstructed images, without compromising the spatial resolution or the wide FOV of lens-free on-chip microscopes. To demonstrate the potential of this lens-free color microscope we imaged stained Papanicolaou (Pap) smears over a wide FOV of ~14 mm2 with sub-micron spatial resolution.

© 2013 OSA

OCIS Codes
(110.0180) Imaging systems : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Imaging Systems

Original Manuscript: March 18, 2013
Revised Manuscript: May 3, 2013
Manuscript Accepted: May 6, 2013
Published: May 14, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Alon Greenbaum, Alborz Feizi, Najva Akbari, and Aydogan Ozcan, "Wide-field computational color imaging using pixel super-resolved on-chip microscopy," Opt. Express 21, 12469-12483 (2013)

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