OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 6 — Jun. 27, 2013

Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules

Mitsuhiro Terakawa, Tatsuki Mitsuhashi, Takuya Shinohara, and Hisashi Shimizu  »View Author Affiliations


Optics Express, Vol. 21, Issue 10, pp. 12604-12610 (2013)
http://dx.doi.org/10.1364/OE.21.012604


View Full Text Article

Enhanced HTML    Acrobat PDF (1090 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Fabrication of a nanopore in a hollow microcapsule was demonstrated using near-infrared femtosecond laser irradiation. The shape of the irradiated microcapsules was kept spherical except for a pore in the shell owing to the nonthermal processing by a femtosecond laser. The simulation results for the near-field and far-field scattering around a microcapsule revealed that highly-enhanced optical intensity can be generated at a spot on the shell of a microcapsule, which would in turn contribute to localized ablation. To the best of our knowledge, this is the first demonstration of the nanoperforation of transparent hollow microcapsules by a near-infrared laser without any doping with absorbing metals or dyes that may cause cell toxicity. The presented method is a promising approach for safer drug delivery and the controlled release of therapeutic drugs.

© 2013 OSA

OCIS Codes
(140.3390) Lasers and laser optics : Laser materials processing
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Laser Microfabrication

History
Original Manuscript: March 19, 2013
Revised Manuscript: May 9, 2013
Manuscript Accepted: May 11, 2013
Published: May 15, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Mitsuhiro Terakawa, Tatsuki Mitsuhashi, Takuya Shinohara, and Hisashi Shimizu, "Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules," Opt. Express 21, 12604-12610 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-10-12604


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. E. Amstad and E. Reimhult, “Nanoparticle actuated hollow drug delivery vehicles,” Nanomedicine (Lond)7(1), 145–164 (2012). [CrossRef] [PubMed]
  2. F. Ungaro, I. d’Angelo, A. Miro, M. I. La Rotonda, and F. Quaglia, “Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises,” J. Pharm. Pharmacol.64(9), 1217–1235 (2012). [CrossRef] [PubMed]
  3. Y. Wang, L. Hosta-Rigau, H. Lomas, and F. Caruso, “Nanostructured polymer assemblies formed at interfaces: applications from immobilization and encapsulation to stimuli-responsive release,” Phys. Chem. Chem. Phys.13(11), 4782–4801 (2011). [CrossRef] [PubMed]
  4. M. Delcea, H. Möhwald, and A. G. Skirtach, “Stimuli-responsive LbL capsules and nanoshells for drug delivery,” Adv. Drug Deliv. Rev.63(9), 730–747 (2011). [CrossRef] [PubMed]
  5. A. J. Chung and M. F. Rubner, “Methods of loading and releasing low molecular weight cationic molecules in weak polyelectrolyte multilayer films,” Langmuir18(4), 1176–1183 (2002). [CrossRef]
  6. K. Köhler, D. G. Shchukin, H. Möhwald, and G. B. Sukhorukov, “Thermal behavior of polyelectrolyte multilayer microcapsules,” J. Phys. Chem. B109(39), 18250–18259 (2005). [CrossRef] [PubMed]
  7. D. G. Shchukin, D. A. Gorin, and H. Möhwald, “Ultrasonically induced opening of polyelectrolyte microcontainers,” Langmuir22(17), 7400–7404 (2006). [CrossRef] [PubMed]
  8. M. F. Bédard, B. G. De Geest, A. G. Skirtach, H. Möhwald, and G. B. Sukhorukov, “Polymeric microcapsules with light responsive properties for encapsulation and release,” Adv. Colloid Interface Sci.158, 2–14 (2010). [PubMed]
  9. A. S. Angelatos, B. Radt, and F. Caruso, “Light-responsive polyelectrolyte/gold nanoparticle microcapsules,” J. Phys. Chem. B109(7), 3071–3076 (2005). [CrossRef] [PubMed]
  10. A. G. Skirtach, A. Muñoz Javier, O. Kreft, K. Köhler, A. Piera Alberola, H. Möhwald, W. J. Parak, and G. B. Sukhorukov, “Laser-induced release of encapsulated materials inside living cells,” Angew. Chem. Int. Ed. Engl.45(28), 4612–4617 (2006). [CrossRef] [PubMed]
  11. Y. Pan, S. Neuss, A. Leifert, M. Fischler, F. Wen, U. Simon, G. Schmid, W. Brandau, and W. Jahnen-Dechent, “Size-dependent cytotoxicity of gold nanoparticles,” Small3(11), 1941–1949 (2007). [CrossRef] [PubMed]
  12. S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicol. In Vitro19(7), 975–983 (2005). [CrossRef] [PubMed]
  13. M. Terakawa, S. Takeda, Y. Tanaka, G. Obara, T. Miyanishi, T. Sakai, T. Sumiyoshi, H. Sekita, M. Hasegawa, P. Viktorovitch, and M. Obara, “Enhanced localized near field and scattered far field for surface nanophotonics applications,” Prog. Quantum Electron.36(1), 194–271 (2012). [CrossRef]
  14. M. Terakawa and Y. Tanaka, “Dielectric microsphere mediated transfection using a femtosecond laser,” Opt. Lett.36(15), 2877–2879 (2011). [CrossRef] [PubMed]
  15. M. Terakawa, Y. Tsunoi, and T. Mitsuhashi, “In vitro perforation of human epithelial carcinoma cell with antibody-conjugated biodegradable microspheres illuminated by a single 80 femtosecond near-infrared laser pulse,” Int. J. Nanomedicine7, 2653–2660 (2012). [CrossRef] [PubMed]
  16. C. B. Schaffer, A. Brodeur, and E. Mazur, “Laser-induced breakdown and damage in bulk transparent materials induced by tightly-focused femtosecond laser pulses,” Meas. Sci. Technol.12(11), 1784–1794 (2001). [CrossRef]
  17. R. R. Gattass and E. Mazur, “Femtosecond laser micromachining in transparent materials,” Nat. Photonics2(4), 219–225 (2008). [CrossRef]
  18. A. Vogel, J. Noack, G. Hüttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B81(8), 1015–1047 (2005). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited