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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 7 — Aug. 1, 2013

High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart

Jinhyoung Park, Thomas M. Cummins, Michael Harrison, Jungwoo Lee, Qifa Zhou, Ching-Ling Lien, and K. Kirk Shung  »View Author Affiliations


Optics Express, Vol. 21, Issue 12, pp. 14636-14642 (2013)
http://dx.doi.org/10.1364/OE.21.014636


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Abstract

A technique on high frame rate(28fps), high frequency co-registered ultrasound and photoacoustic imaging for visualizing zebrafish heart blood flow was demonstrated. This approach was achieved with a 40MHz light weight(0.38g) ring-type transducer, serving as the ultrasound transmitter and receiver, to allow an optic fiber, coupled with a 532nm laser, to be inserted into the hole. From the wire target study, axial resolutions of 38µm and 42µm were obtained for ultrasound and photoacoustic imaging, respectively. Carbon nanotubes were utilized as contrast agents to increase the flow signal level by 20dB in phantom studies, and zebrafish heart blood flow was successfully observed.

© 2013 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.5120) Imaging systems : Photoacoustic imaging

ToC Category:
Imaging Systems

History
Original Manuscript: April 4, 2013
Revised Manuscript: May 23, 2013
Manuscript Accepted: May 31, 2013
Published: June 12, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Jinhyoung Park, Thomas M. Cummins, Michael Harrison, Jungwoo Lee, Qifa Zhou, Ching-Ling Lien, and K. Kirk Shung, "High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart," Opt. Express 21, 14636-14642 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-12-14636


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References

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