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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 3 — Apr. 4, 2013

Quantitative X-ray phase-contrast computed tomography at 82 keV

Marian Willner, Martin Bech, Julia Herzen, Irene Zanette, Dieter Hahn, Johannes Kenntner, Juergen Mohr, Alexander Rack, Timm Weitkamp, and Franz Pfeiffer  »View Author Affiliations


Optics Express, Vol. 21, Issue 4, pp. 4155-4166 (2013)
http://dx.doi.org/10.1364/OE.21.004155


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Abstract

Potential applications of grating-based X-ray phase-contrast imaging are investigated in various fields due to its compatibility with laboratory X-ray sources. So far the method was mainly restricted to X-ray energies below 40 keV, which is too low to examine dense or thick objects, but a routine operation at higher energies is on the brink of realisation. In this study, imaging results obtained at 82 keV are presented. These comprise a test object consisting of well-defined materials for a quantitative analysis and a tooth to translate the findings to a biomedical sample. Measured linear attenuation coefficients μ and electron densities ρe are in good agreement with theoretical values. Improved contrast-to-noise ratios were found in phase contrast compared to attenuation contrast. The combination of both contrast modalities further enables to simultaneously assess information on density and composition of materials with effective atomic numbers Z̃ > 8. In our biomedical example, we demonstrate the possibility to detect differences in mass density and calcium concentration within teeth.

© 2013 OSA

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
X-ray Optics

History
Original Manuscript: January 3, 2013
Revised Manuscript: January 25, 2013
Manuscript Accepted: January 30, 2013
Published: February 11, 2013

Virtual Issues
Vol. 8, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Marian Willner, Martin Bech, Julia Herzen, Irene Zanette, Dieter Hahn, Johannes Kenntner, Juergen Mohr, Alexander Rack, Timm Weitkamp, and Franz Pfeiffer, "Quantitative X-ray phase-contrast computed tomography at 82 keV," Opt. Express 21, 4155-4166 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-4-4155


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