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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 3 — Apr. 4, 2013

Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

Nathan R. Gemmell, Aongus McCarthy, Baochang Liu, Michael G. Tanner, Sander D. Dorenbos, Valery Zwiller, Michael S. Patterson, Gerald S. Buller, Brian C. Wilson, and Robert H. Hadfield  »View Author Affiliations


Optics Express, Vol. 21, Issue 4, pp. 5005-5013 (2013)
http://dx.doi.org/10.1364/OE.21.005005


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Abstract

Direct monitoring of singlet oxygen (1O2) luminescence is a particularly challenging infrared photodetection problem. 1O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record 1O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the 1O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of 1O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.

© 2013 OSA

OCIS Codes
(030.5260) Coherence and statistical optics : Photon counting
(040.3780) Detectors : Low light level
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(250.5230) Optoelectronics : Photoluminescence
(270.5570) Quantum optics : Quantum detectors
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence
(350.5130) Other areas of optics : Photochemistry

ToC Category:
Detectors

History
Original Manuscript: November 29, 2012
Revised Manuscript: January 16, 2013
Manuscript Accepted: January 17, 2013
Published: February 21, 2013

Virtual Issues
Vol. 8, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Nathan R. Gemmell, Aongus McCarthy, Baochang Liu, Michael G. Tanner, Sander D. Dorenbos, Valery Zwiller, Michael S. Patterson, Gerald S. Buller, Brian C. Wilson, and Robert H. Hadfield, "Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector," Opt. Express 21, 5005-5013 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-4-5005


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