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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 3 — Apr. 4, 2013

Using high frequency Raman spectra for colonic neoplasia detection

Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng  »View Author Affiliations

Optics Express, Vol. 21, Issue 4, pp. 5025-5034 (2013)

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Raman systems have tremendous potential as adjunct devices for endoscopes to improve the identification of early colon cancers. However, the traditional low frequency (LF) measurement range has several obstacles that make it challenging to develop a routine clinical tool. An alternative is to use high frequency (HF) range. To test this idea Raman spectra were obtained in both the LF and HF ranges from the same colon lesions. Multivariate analyses predicted the pathology with high sensitivity and specificity for both the LF and HF data sets. This suggests that Raman systems that measure HF spectra, and are simpler to adopt into the clinic, could be used in vivo to improve the identification of neoplastic lesions.

© 2013 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 3, 2012
Revised Manuscript: February 14, 2013
Manuscript Accepted: February 15, 2013
Published: February 21, 2013

Virtual Issues
Vol. 8, Iss. 3 Virtual Journal for Biomedical Optics

Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng, "Using high frequency Raman spectra for colonic neoplasia detection," Opt. Express 21, 5025-5034 (2013)

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