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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 4 — May. 22, 2013

Plasmonic interferometers for label-free multiplexed sensing

Yongkang Gao, Zheming Xin, Qiaoqiang Gan, Xuanhong Cheng, and Filbert J. Bartoli  »View Author Affiliations


Optics Express, Vol. 21, Issue 5, pp. 5859-5871 (2013)
http://dx.doi.org/10.1364/OE.21.005859


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Abstract

We report a plasmonic interferometric biosensor based on a simple slit-groove metallic nanostructure that monitors the phase changes of surface plasmon polaritons resulting from biomolecular adsorptions. The proposed sensing scheme integrates the strengths of miniaturized plasmonic architectures with sensitive optical interferometry techniques. Sensing peak linewidths as narrow as 7 nm and refractive index resolutions of 1 × 10−5 RIU were experimentally measured from a miniaturized sensing area of 10 × 30 µm2 using a collinear transmission setup and a low-cost compact spectrometer. A high-density array of such interferometric sensors was also fabricated to demonstrate its potential for real-time multiplexed sensing using a CCD camera for intensity interrogation. A self-referencing method was introduced to increase the sensitivity and reduce sensor noise for multiplexing measurements. The enhanced sensing performance, small sensor footprint, and simple instrumentation and optical alignment suggest promise to integrate this platform into low-cost label-free biosensing devices with high multiplexing capabilities.

© 2013 OSA

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(130.6010) Integrated optics : Sensors
(240.6680) Optics at surfaces : Surface plasmons
(220.4241) Optical design and fabrication : Nanostructure fabrication
(250.5403) Optoelectronics : Plasmonics

ToC Category:
Sensors

History
Original Manuscript: December 19, 2012
Revised Manuscript: January 30, 2013
Manuscript Accepted: January 30, 2013
Published: March 1, 2013

Virtual Issues
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Yongkang Gao, Zheming Xin, Qiaoqiang Gan, Xuanhong Cheng, and Filbert J. Bartoli, "Plasmonic interferometers for label-free multiplexed sensing," Opt. Express 21, 5859-5871 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-5-5859


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References

  1. C. Genet and T. W. Ebbesen, “Light in tiny holes,” Nature445(7123), 39–46 (2007). [CrossRef] [PubMed]
  2. J. A. Schuller, E. S. Barnard, W. Cai, Y. C. Jun, J. S. White, and M. L. Brongersma, “Plasmonics for extreme light concentration and manipulation,” Nat. Mater.9(3), 193–204 (2010). [CrossRef] [PubMed]
  3. S. A. Maier, Plasmonics: Fundamental and Applications (Springer, 2007).
  4. J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev.108(2), 462–493 (2008). [CrossRef] [PubMed]
  5. A. De Leebeeck, L. K. S. Kumar, V. de Lange, D. Sinton, R. Gordon, and A. G. Brolo, “On-chip surface-based detection with nanohole arrays,” Anal. Chem.79(11), 4094–4100 (2007). [CrossRef] [PubMed]
  6. A. Cattoni, P. Ghenuche, A. M. Haghiri-Gosnet, D. Decanini, J. Chen, J. L. Pelouard, and S. Collin, “λ³/1000 Plasmonic Nanocavities for Biosensing Fabricated by Soft UV Nanoimprint Lithography,” Nano Lett.11(9), 3557–3563 (2011). [CrossRef] [PubMed]
  7. G. Spoto and M. Minunni, “Surface plasmon resonance imaging: what next?” J. Phys. Chem. Lett.3(18), 2682–2691 (2012). [CrossRef]
  8. N. C. Lindquist, A. Lesuffleur, H. Im, and S. H. Oh, “Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation,” Lab Chip9(3), 382–387 (2009). [CrossRef] [PubMed]
  9. K. A. Tetz, L. Pang, and Y. Fainman, “High-resolution surface plasmon resonance sensor based on linewidth-optimized nanohole array transmittance,” Opt. Lett.31(10), 1528–1530 (2006). [CrossRef] [PubMed]
  10. J. C. Yang, J. Ji, J. M. Hogle, and D. N. Larson, “Multiplexed plasmonic sensing based on small-dimension nanohole arrays and intensity interrogation,” Biosens. Bioelectron.24(8), 2334–2338 (2009). [CrossRef] [PubMed]
  11. C. T. Campbell and G. Kim, “SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics,” Biomaterials28(15), 2380–2392 (2007). [CrossRef] [PubMed]
  12. M. E. Stewart, C. R. Anderton, L. B. Thompson, J. Maria, S. K. Gray, J. A. Rogers, and R. G. Nuzzo, “Nanostructured plasmonic sensors,” Chem. Rev.108(2), 494–521 (2008). [CrossRef] [PubMed]
  13. J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater.7(6), 442–453 (2008). [CrossRef] [PubMed]
  14. K. M. Mayer and J. H. Hafner, “Localized surface plasmon resonance sensors,” Chem. Rev.111(6), 3828–3857 (2011). [CrossRef] [PubMed]
  15. K.-L. Lee, P.-W. Chen, S.-H. Wu, J.-B. Huang, S.-Y. Yang, and P.-K. Wei, “Enhancing surface plasmon detection using template-stripped gold nanoslit arrays on plastic films,” ACS Nano6(4), 2931–2939 (2012). [CrossRef] [PubMed]
  16. A. A. Yanik, A. E. Cetin, M. Huang, A. Artar, S. H. Mousavi, A. Khanikaev, J. H. Connor, G. Shvets, and H. Altug, “Seeing protein monolayers with naked eye through plasmonic Fano resonances,” Proc. Natl. Acad. Sci. U.S.A.108(29), 11784–11789 (2011). [CrossRef] [PubMed]
  17. H. Im, A. Lesuffleur, N. C. Lindquist, and S. H. Oh, “Plasmonic nanoholes in a multichannel microarray format for parallel kinetic assays and differential sensing,” Anal. Chem.81(8), 2854–2859 (2009). [CrossRef] [PubMed]
  18. N. Verellen, P. Van Dorpe, C. J. Huang, K. Lodewijks, G. A. E. Vandenbosch, L. Lagae, and V. V. Moshchalkov, “Plasmon line shaping using nanocrosses for high sensitivity localized surface plasmon resonance sensing,” Nano Lett.11(2), 391–397 (2011). [CrossRef] [PubMed]
  19. S. Zhang, K. Bao, N. J. Halas, H. Xu, and P. Nordlander, “Substrate-induced Fano resonances of a plasmonic nanocube: a route to increased-sensitivity localized surface plasmon resonance sensors revealed,” Nano Lett.11(4), 1657–1663 (2011). [CrossRef] [PubMed]
  20. N. Liu, T. Weiss, M. Mesch, L. Langguth, U. Eigenthaler, M. Hirscher, C. Sönnichsen, and H. Giessen, “Planar metamaterial analogue of electromagnetically induced transparency for plasmonic sensing,” Nano Lett.10(4), 1103–1107 (2010). [CrossRef] [PubMed]
  21. B. Auguié and W. L. Barnes, “Collective resonances in gold nanoparticle arrays,” Phys. Rev. Lett.101(14), 143902 (2008). [CrossRef] [PubMed]
  22. Y. Gao, Q. Gan, Z. Xin, X. Cheng, and F. J. Bartoli, “Plasmonic Mach-Zehnder interferometer for ultrasensitive on-chip biosensing,” ACS Nano5(12), 9836–9844 (2011). [CrossRef] [PubMed]
  23. Q. Gan, Y. Gao, and F. J. Bartoli, “Vertical plasmonic Mach-Zehnder interferometer for sensitive optical sensing,” Opt. Express17(23), 20747–20755 (2009). [CrossRef] [PubMed]
  24. X. Wu, J. Zhang, J. Chen, C. Zhao, and Q. Gong, “Refractive index sensor based on surface-plasmon interference,” Opt. Lett.34(3), 392–394 (2009). [CrossRef] [PubMed]
  25. J. Feng, V. S. Siu, A. Roelke, V. Mehta, S. Y. Rhieu, G. T. R. Palmore, and D. Pacifici, “Nanoscale plasmonic interferometers for multispectral, high-throughput biochemical sensing,” Nano Lett.12(2), 602–609 (2012). [CrossRef] [PubMed]
  26. X. Li, Q. Tan, B. Bai, and G. Jin, “Non-spectroscopic refractometric nanosensor based on a tilted slit-groove plasmonic interferometer,” Opt. Express19(21), 20691–20703 (2011). [CrossRef] [PubMed]
  27. O. Yavas and C. Kocabas, “Plasmon interferometers for high-throughput sensing,” Opt. Lett.37(16), 3396–3398 (2012). [CrossRef]
  28. J. Bravo-Abad, L. Martín-Moreno, and F. J. García-Vidal, “Transmission properties of a single metallic slit: From the subwavelength regime to the geometrical-optics limit,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys.69(2), 026601 (2004). [CrossRef] [PubMed]
  29. A. B. Dahlin, S. Chen, M. P. Jonsson, L. Gunnarsson, M. Käll, and F. Höök, “High-resolution microspectroscopy of plasmonic nanostructures for miniaturized biosensing,” Anal. Chem.81(16), 6572–6580 (2009). [CrossRef] [PubMed]
  30. Q. Gan, Y. Gao, Q. Wang, L. Zhu, and F. J. Bartoli, “Surface plasmon waves generated by nanogrooves through spectral interference,” Phys. Rev. B81(8), 085443 (2010). [CrossRef]
  31. M. E. Stewart, N. H. Mack, V. Malyarchuk, J. A. Soares, T. W. Lee, S. K. Gray, R. G. Nuzzo, and J. A. Rogers, “Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals,” Proc. Natl. Acad. Sci. U.S.A.103(46), 17143–17148 (2006). [CrossRef] [PubMed]
  32. V. V. Temnov, U. Woggon, J. Dintinger, E. Devaux, and T. W. Ebbesen, “Surface plasmon interferometry: measuring group velocity of surface plasmons,” Opt. Lett.32(10), 1235–1237 (2007). [CrossRef] [PubMed]
  33. E. D. Palik, Handbook of Optical Constants of Solids (Academic Press, 1998).
  34. J. Henzie, M. H. Lee, and T. W. Odom, “Multiscale patterning of plasmonic metamaterials,” Nat. Nanotechnol.2(9), 549–554 (2007). [CrossRef] [PubMed]
  35. P. Lalanne, J. P. Hugonin, and J. C. Rodier, “Theory of surface plasmon generation at nanoslit apertures,” Phys. Rev. Lett.95(26), 263902 (2005). [CrossRef] [PubMed]
  36. J. S. Q. Liu, R. A. Pala, F. Afshinmanesh, W. Cai, and M. L. Brongersma, “A submicron plasmonic dichroic splitter,” Nat Commun2, 525 (2011). [CrossRef] [PubMed]
  37. M. U. Gonzalez, J. C. Weeber, A. L. Baudrion, A. Dereux, A. L. Stepanov, J. R. Krenn, E. Devaux, and T. W. Ebbesen, “Design, near-field characterization, and modeling of 45° surface-plasmon Bragg mirrors,” Phys. Rev. B73(15), 155416 (2006). [CrossRef]
  38. J. A. Sanchez-Gil and A. A. Maradudin, “Surface-plasmon polariton scattering from a finite array of nanogrooves/ridges: Efficient mirrors,” Appl. Phys. Lett.86(25), 251106 (2005). [CrossRef]
  39. P. Nagpal, N. C. Lindquist, S. H. Oh, and D. J. Norris, “Ultrasmooth patterned metals for plasmonics and metamaterials,” Science325(5940), 594–597 (2009). [CrossRef] [PubMed]
  40. L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, “Quantitative interpretation of the response of surface plasmon resonance sensors to adsorbed films,” Langmuir14(19), 5636–5648 (1998). [CrossRef]
  41. S. Sjölander and C. Urbaniczky, “Integrated fluid handling system for biomolecular interaction analysis,” Anal. Chem.63(20), 2338–2345 (1991). [CrossRef] [PubMed]
  42. C. Escobedo, S. Vincent, A. I. K. Choudhury, J. Campbell, A. G. Brolo, D. Sinton, and R. Gordon, “Integrated nanohole array surface plasmon resonance sensing device using a dual-wavelength source,” J. Micromech. Microeng.21(11), 115001 (2011). [CrossRef]
  43. N. C. Lindquist, T. W. Johnson, D. J. Norris, and S. H. Oh, “Monolithic integration of continuously tunable plasmonic nanostructures,” Nano Lett.11(9), 3526–3530 (2011). [CrossRef] [PubMed]
  44. H. Im, S. H. Lee, N. J. Wittenberg, T. W. Johnson, N. C. Lindquist, P. Nagpal, D. J. Norris, and S. H. Oh, “Template-stripped smooth Ag nanohole arrays with silica shells for surface plasmon resonance biosensing,” ACS Nano5(8), 6244–6253 (2011). [CrossRef] [PubMed]

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