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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 5 — Jun. 6, 2013

Optical phase conjugation (OPC)-assisted isotropic focusing

Mooseok Jang, Anne Sentenac, and Changhuei Yang  »View Author Affiliations


Optics Express, Vol. 21, Issue 7, pp. 8781-8792 (2013)
http://dx.doi.org/10.1364/OE.21.008781


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Abstract

Isotropic optical focusing – the focusing of light with axial confinement that matches its lateral confinement, is important for a broad range of applications. Conventionally, such focusing is achieved by overlapping the focused beams from a pair of opposite-facing microscope objective lenses. However the exacting requirements for the alignment of the objective lenses and the method’s relative intolerance to sample turbidity have significantly limited its utility. In this paper, we present an optical phase conjugation (OPC)-assisted isotropic focusing method that can address both challenges. We exploit the time-reversal nature of OPC playback to naturally guarantee the overlap of the two focused beams even when the objective lenses are significantly misaligned (up to 140 microns transversely and 80 microns axially demonstrated). The scattering correction capability of OPC also enabled us to accomplish isotropic focusing through thick scattering samples (demonstrated with samples of ~7 scattering mean free paths). This method can potentially improve 4Pi microscopy and 3D microstructure patterning.

© 2013 OSA

OCIS Codes
(070.5040) Fourier optics and signal processing : Phase conjugation
(090.2880) Holography : Holographic interferometry
(110.7050) Imaging systems : Turbid media
(220.1000) Optical design and fabrication : Aberration compensation
(090.1995) Holography : Digital holography
(220.1080) Optical design and fabrication : Active or adaptive optics

ToC Category:
Holography

History
Original Manuscript: February 26, 2013
Revised Manuscript: March 22, 2013
Manuscript Accepted: March 23, 2013
Published: April 2, 2013

Virtual Issues
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Mooseok Jang, Anne Sentenac, and Changhuei Yang, "Optical phase conjugation (OPC)-assisted isotropic focusing," Opt. Express 21, 8781-8792 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-21-7-8781


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