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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 4 — Apr. 1, 2014

Towards acousto-optic tissue imaging with nanosecond laser pulses

S.G. Resink, E. Hondebrink, and W. Steenbergen  »View Author Affiliations


Optics Express, Vol. 22, Issue 3, pp. 3564-3571 (2014)
http://dx.doi.org/10.1364/OE.22.003564


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Abstract

We present a way to generate acousto-optical signals in timovssue-like media with nanosecond laser pulses. Our method is based on recording and analyzing speckle patterns formed by interaction of nanosecond laser pulses with tissue, without and with simultaneous application of ultrasound. Stroboscopic application allows visualizing the temporal behavior of speckles while the ultrasound is propagating through the medium. We investigate two ways of quantifying the acousto-optic effect, viz. adding and subtracting speckle patterns obtained at various ultrasound phases. Both methods are compared with the existing speckle contrast method using a 2D scan and are found to perform similarly. Our method gives outlook on overcoming the speckle decorrelation problem in acousto-optics, and therefore brings in-vivo acousto-optic measurements one step closer. Furthermore it enables combining acousto-optics and photoacoustics in one setup with a single laser.

© 2014 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(070.1060) Fourier optics and signal processing : Acousto-optical signal processing
(170.1065) Medical optics and biotechnology : Acousto-optics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 6, 2013
Revised Manuscript: January 29, 2014
Manuscript Accepted: January 30, 2014
Published: February 6, 2014

Virtual Issues
Vol. 9, Iss. 4 Virtual Journal for Biomedical Optics

Citation
S.G. Resink, E. Hondebrink, and W. Steenbergen, "Towards acousto-optic tissue imaging with nanosecond laser pulses," Opt. Express 22, 3564-3571 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-22-3-3564


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References

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