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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 5 — Apr. 29, 2014

X-ray micro-modulated luminescence tomography (XMLT)

Wenxiang Cong, Fenglin Liu, Chao Wang, and Ge Wang  »View Author Affiliations


Optics Express, Vol. 22, Issue 5, pp. 5572-5580 (2014)
http://dx.doi.org/10.1364/OE.22.005572


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Abstract

Imaging depth of optical microscopy has been fundamentally limited to millimeter or sub-millimeter due to strong scattering of light in a biological sample. X-ray microscopy can resolve spatial details of few microns deep inside a sample but contrast resolution is inadequate to depict heterogeneous features at cellular or sub-cellular levels. To enhance and enrich biological contrast at large imaging depth, various nanoparticles are introduced and become essential to basic research and molecular medicine. Nanoparticles can be functionalized as imaging probes, similar to fluorescent and bioluminescent proteins. LiGa5O8:Cr3+ nanoparticles were recently synthesized to facilitate luminescence energy storage with x-ray pre-excitation and subsequently stimulated luminescence emission by visible/near-infrared (NIR) light. In this paper, we propose an x-ray micro-modulated luminescence tomography (XMLT, or MLT to be more general) approach to quantify a nanophosphor distribution in a thick biological sample with high resolution. Our numerical simulation studies demonstrate the feasibility of the proposed approach.

© 2014 Optical Society of America

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(340.0340) X-ray optics : X-ray optics

ToC Category:
X-ray Optics

History
Original Manuscript: November 15, 2013
Revised Manuscript: December 26, 2013
Manuscript Accepted: January 13, 2014
Published: March 4, 2014

Virtual Issues
Vol. 9, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Wenxiang Cong, Fenglin Liu, Chao Wang, and Ge Wang, "X-ray micro-modulated luminescence tomography (XMLT)," Opt. Express 22, 5572-5580 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-22-5-5572


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