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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 4 — Apr. 12, 2006

Fast, flexible algorithm for calculating photon correlations

Ted A. Laurence, Samantha Fore, and Thomas Huser  »View Author Affiliations

Optics Letters, Vol. 31, Issue 6, pp. 829-831 (2006)

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We introduce a new algorithm for computing correlations of photon arrival time data acquired in single-molecule fluorescence spectroscopy and fluorescence correlation spectroscopy (FCS). The algorithm is based on rewriting the correlation as a counting operation on photon pairs and can be used with arbitrary bin widths and spacing. The flexibility of the algorithm is demonstrated by use of FCS simulations and single-molecule photon antibunching experiments. Execution speed is comparable to the commonly used multiple-tau correlation technique. Wide bin spacings are possible that allow for real-time software calculation of correlations, even for high count rates.

© 2006 Optical Society of America

OCIS Codes
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(180.1790) Microscopy : Confocal microscopy
(300.2530) Spectroscopy : Fluorescence, laser-induced

ToC Category:

Original Manuscript: October 24, 2005
Manuscript Accepted: November 11, 2005

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Ted A. Laurence, Samantha Fore, and Thomas Huser, "Fast, flexible algorithm for calculating photon correlations," Opt. Lett. 31, 829-831 (2006)

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