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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 5 — May. 5, 2006

Confocal reflectance theta line scanning microscope for imaging human skin in vivo

Peter J. Dwyer, Charles A. DiMarzio, James M. Zavislan, William J. Fox, and Milind Rajadhyaksha  »View Author Affiliations


Optics Letters, Vol. 31, Issue 7, pp. 942-944 (2006)
http://dx.doi.org/10.1364/OL.31.000942


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Abstract

A confocal reflectance theta line scanning microscope demonstrates imaging of nuclear and cellular detail in human epidermis in vivo. Experimentally measured line-spread functions determine the instrumental optical section thickness to be 1.7 ± 0.1 μ m and the lateral resolution to be 1.0 ± 0.1 μ m . Within human dermis (through full-thickness epidermis), the measured section thickness is 9.2 ± 1.7 μ m and the lateral resolution is 1.7 ± 0.1 μ m . An illumination line is scanned directly in the pupil of the objective lens, and the backscattered descanned light is detected with a linear array, such that the theta line scanner consists of only seven optical components.

© 2006 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.1790) Medical optics and biotechnology : Confocal microscopy
(180.1790) Microscopy : Confocal microscopy
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Microscopy

History
Original Manuscript: August 30, 2005
Revised Manuscript: November 9, 2005
Manuscript Accepted: November 30, 2005

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Peter J. Dwyer, Charles A. DiMarzio, James M. Zavislan, William J. Fox, and Milind Rajadhyaksha, "Confocal reflectance theta line scanning microscope for imaging human skin in vivo," Opt. Lett. 31, 942-944 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-31-7-942

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