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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 5 — May. 5, 2006

Spectroscopic spectral-domain optical coherence microscopy

Chengyang Xu, Claudio Vinegoni, Tyler S. Ralston, Wei Luo, Wei Tan, and Stephen A. Boppart  »View Author Affiliations


Optics Letters, Vol. 31, Issue 8, pp. 1079-1081 (2006)
http://dx.doi.org/10.1364/OL.31.001079


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Abstract

The spectroscopic content within optical coherence tomography (OCT) data can provide a wealth of information. Spectroscopic OCT methods are frequently limited by time-frequency trade-offs that limit high spectral and spatial resolution simultaneously. We present spectroscopic spectral-domain optical coherence microscopy performed with a multimodality microscope. Restricting the spatial extent of the signal by using high-numerical-aperture optics makes high-resolution spectroscopic information accessible, facilitated with spectral-domain detection. Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells.

© 2006 Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(190.4180) Nonlinear optics : Multiphoton processes
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 13, 2005
Revised Manuscript: December 30, 2005
Manuscript Accepted: January 3, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Chengyang Xu, Claudio Vinegoni, Tyler S. Ralston, Wei Luo, Wei Tan, and Stephen A. Boppart, "Spectroscopic spectral-domain optical coherence microscopy," Opt. Lett. 31, 1079-1081 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-31-8-1079

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