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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 7 — Jul. 16, 2007

Optical coherence tomography with plasmon resonant nanorods of gold

Timothy S. Troutman, Jennifer K. Barton, and Marek Romanowski  »View Author Affiliations

Optics Letters, Vol. 32, Issue 11, pp. 1438-1440 (2007)

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We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, and OCT. Polyacrylamide-based phantoms were generated with appropriate scattering and anisotropy coefficients ( 30 cm 1 and 0.89, respectively) to image distribution of the contrast agent in an environment similar to that of tissue. The observed signal was dependent on whether the plasmon resonance peak overlapped the source bandwidth of the OCT, confirming the resonant character of enhancement. Gold nanorods with plasmon resonance wavelengths overlapping the OCT source yielded a signal-to-background ratio of 4.5 dB , relative to the tissue phantom. Strategies for OCT imaging with nanorods are discussed.

© 2007 Optical Society of America

OCIS Codes
(160.3900) Materials : Metals
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.5850) Scattering : Scattering, particles

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 2, 2007
Revised Manuscript: March 11, 2007
Manuscript Accepted: March 28, 2007
Published: May 1, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Timothy S. Troutman, Jennifer K. Barton, and Marek Romanowski, "Optical coherence tomography with plasmon resonant nanorods of gold," Opt. Lett. 32, 1438-1440 (2007)

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