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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 7 — Jul. 16, 2007

Imaging voltage-dependent cell motions with heterodyne Mach–Zehnder phase microscopy

Christopher Fang-Yen, Seungeun Oh, Yongkeun Park, Wonshik Choi, Sen Song, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 32, Issue 11, pp. 1572-1574 (2007)
http://dx.doi.org/10.1364/OL.32.001572


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Abstract

We describe a heterodyne Mach–Zehnder interferometric microscope capable of quantitative phase imaging of biological samples with subnanometer sensitivity and frame rates up to 10 kHz . We use the microscope to image cultured neurons and measure nanometer-scale voltage-dependent motions in cells expressing the membrane motor protein prestin.

© 2007 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 8, 2007
Manuscript Accepted: March 26, 2007
Published: May 18, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Christopher Fang-Yen, Seungeun Oh, Yongkeun Park, Wonshik Choi, Sen Song, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld, "Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy," Opt. Lett. 32, 1572-1574 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-32-11-1572


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