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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 7 — Jul. 16, 2007

Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture

Larry K. Wong, Michael J. Mandella, Gordon S. Kino, and Thomas D. Wang  »View Author Affiliations


Optics Letters, Vol. 32, Issue 12, pp. 1674-1676 (2007)
http://dx.doi.org/10.1364/OL.32.001674


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Abstract

We perform Monte Carlo simulations to show that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis. As a result, the DA configuration provides improved signal-to-noise ratio and dynamic range, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue.

© 2007 Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.5280) Medical optics and biotechnology : Photon migration
(170.6930) Medical optics and biotechnology : Tissue
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 2, 2007
Revised Manuscript: March 30, 2007
Manuscript Accepted: April 20, 2007
Published: June 5, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Larry K. Wong, Michael J. Mandella, Gordon S. Kino, and Thomas D. Wang, "Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture," Opt. Lett. 32, 1674-1676 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-32-12-1674

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