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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 10 — Oct. 31, 2007

Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Xianfeng Chen, Lin Zhang, Kaiming Zhou, Edward Davies, Kate Sugden, Ian Bennion, Marcus Hughes, and Anna Hine  »View Author Affiliations


Optics Letters, Vol. 32, Issue 17, pp. 2541-2543 (2007)
http://dx.doi.org/10.1364/OL.32.002541


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Abstract

Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability.

© 2007 Optical Society of America

OCIS Codes
(050.2770) Diffraction and gratings : Gratings
(060.2370) Fiber optics and optical communications : Fiber optics sensors

ToC Category:
Fiber Optics and Optical Communications

History
Original Manuscript: May 17, 2007
Revised Manuscript: July 13, 2007
Manuscript Accepted: July 14, 2007
Published: August 20, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Xianfeng Chen, Lin Zhang, Kaiming Zhou, Edward Davies, Kate Sugden, Ian Bennion, Marcus Hughes, and Anna Hine, "Real-time detection of DNA interactions with long-period fiber-grating-based biosensor," Opt. Lett. 32, 2541-2543 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-32-17-2541

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