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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 10 — Oct. 31, 2007

Guiding a confocal microscope by single fluorescent nanoparticles

Hu Cang, C. Shan Xu, Daniel Montiel, and Haw Yang  »View Author Affiliations


Optics Letters, Vol. 32, Issue 18, pp. 2729-2731 (2007)
http://dx.doi.org/10.1364/OL.32.002729


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Abstract

Confocal optical microscopes offer unparalleled high sensitivity and three-dimensional (3D) imaging capability but require slow point-by-point scanning; they are inefficient for imaging moving objects. We propose a more efficient solution. Instead of indiscriminate scanning, we let the focus of the microscope pursue the object of interest such that no time is wasted on uninformative background, allowing us to visualize 3D trajectories of fluorescent nanoparticles in solution with millisecond temporal and 200 nm spatial resolution.

© 2007 Optical Society of America

OCIS Codes
(180.1790) Microscopy : Confocal microscopy
(180.2520) Microscopy : Fluorescence microscopy
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Microscopy

History
Original Manuscript: July 25, 2007
Manuscript Accepted: August 7, 2007
Published: September 12, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Hu Cang, C. Shan Xu, Daniel Montiel, and Haw Yang, "Guiding a confocal microscope by single fluorescent nanoparticles," Opt. Lett. 32, 2729-2731 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-32-18-2729

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